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Revista de Nefrología, Diálisis y Trasplante

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2024, Number 4

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Rev Nefrol Dial Traspl 2024; 44 (4)

First experience of using a hypothermic perfusion machine in kidney transplant in Argentina

Schiavelli R, Sánchez N, Mosna L, Menna JL, Fuentes G, Hidalgo G, Vila A, Vega L, Raño J, Roses J, Bisigniano L, Antik A, Mera V, López ML, Yrbas MÁ, Ajzenszlos M, Maiolo E, Soratti C
Full text How to cite this article

Language: Spanish
References: 22
Page: 182-189
PDF size: 415.76 Kb.


Key words:

Donors with expanded criteria, Hypothermic perfusion machine, Organ preservation, Organ allocation policy.

ABSTRACT

Introduction: Argentina has high rates of delayed graft function (DGF). Renal machine perfusion decreases DGF. INCUCAI incorporated two renal perfusion machines (RPMs) into the transplant system and chose Argerich Hospital for their implementation. Objective: To assess the logistics, safety, and coordination of incorporating RPMs in Argentina. Methods: Travel times were assessed; culture tests of preand post-perfusion preservation solutions were performed. Results: Ten previously discarded deceased donor kidneys were perfused without complications. Conclusion: The times observed were as expected from our healthcare system. The procedure was safe, with equal or less isolation of germs after perfusion. This first experience in Argentina shows INCUCAI’s incorporation of new transplant technology and Argerich Hospital’s optimal adaptation to this practice.


REFERENCES

  1. Port FK, Bragg-Gresham JL, Metzger RA, et al. Donorcharacteristics associated with reduced graft survival:an approach to expanding the pool of kidney donors.Transplantation, 2002; 74(9): 1281-6.

  2. Doyle MB, Collins K, Vachharajani N, Lowell JA,Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J,et al. Outcomes using grafts from donors after cardiacdeath. J Am Coll Surg, 2015;221(1):142-52.

  3. Kokkinos C, Antcliffe D, Nanidis T, Darzi AW, TekkisP, Papalois V. Outcome of kidney transplantationfrom nonheart-beating versus heart-beating cadavericdonors. Transplantation, 2007;83:1193e9.

  4. Saidi RF, Elias N, Kawai T, et al. Outcome of kidneytransplantation using expanded criteria donors anddonation after cardiac death kidneys: realities andcosts. Am J Transplant, 2007;7(12):2769-74.

  5. Schiavelli R. Estudio multicéntrico y retrospectivode incidencia de retardo de la función renal. CongresoArgentino de Trasplante, II Congreso Argentino de Enfermeríaen Trasplante, noviembre de 2007.

  6. Schiavelli et al. Incidence and effect on survival ofdelayed graft function in donor-deceased kidneytransplants in Argentina: a multicenter analysis. 29thInternational Congress of The Transplantation Society (TTS2022) | Buenos Aires - Argentina | September 10-14,2022

  7. Schiavelli R, Rosés J, Di Tullio D, Gautos A,Sabbatiello R, Pattin M, Raño M. Retraso de la funcióndel injerto en trasplante renal. Nefrol. Diálisis. Traspl,2015;35(4):182-7.

  8. Gallinat A, Moers C, Treckmann J, et al. Machineperfusion versus cold storage for the preservationof kidneys from donors 65 years allocated in theEurotransplant Senior Programme. Nephrol DialTransplant, 2012;27(12):4458-63.

  9. Treckmann J, Moers C, Smits JM, et al. Machineperfusion versus cold storage for preservation ofkidneys from expanded criteria donors after braindeath. Transplant Int, 2011;24(6):548-54.

  10. WCN24-1598 evaluation of the outcome of kidneysimplanted from a discarded pair in the province ofBuenos Aires, Argentina Petrone, Hugo et al. KidneyInternational Reports, Volume 9, Issue 4, S470-S471

  11. Taylor M, Baicu S. Current state of hypothermicmachine perfusion preservation of organs: the clinicalperspective. Cryobiolog y, 2010;60: S20–S35.

  12. Lorusso N, Llanos-Méndez A, Romero-TabaresA. Seguridad y efectividad de las máquinas de perfusión enlos trasplantes de órganos sólidos. Sevilla: Agencia deEvaluación de Tecnologías Sanitarias de Andalucía,2016.

  13. Resoluciones, disponibles en: https://www.argentina.gob.ar/salud/incucai/comunidad-hospitalaria/pasosoperativos.[Consulta realizada el 25 de septiembre de2023].

  14. C Matos AC, Requiao Moura LR, Borrelli M,Nogueira M, Clarizia G, Ongaro P, et al. Impact ofmachine perfusion after long static cold storage ondelayed graft function incidence and duration andtime to hospital discharge. Clin Transplant, 2018; 32(1).

  15. Osband AJ, James NT, Segev DL. Extraction timeof kidneys from deceased donors and impact onoutcomes. Am J Transplant, 2016; 16(2): 700-3.

  16. Slagter JS, Rijkse E, De Wilde RF, Haen R, LepieszaA, Cappelle ML, Kimenai DHJAN, Minnee RC.The effect of recipient back-table duration on graftoutcome of deceased donor kidneys: a single-centerprospective cohort study. J Clin Med, 2023;12(7):2647.

  17. Ranghino A, Diena D, Simonato F, Messina M,Burdese M, Piraina V, et al. Clinical impact ofbacterial contamination of perfusion fluid in kidneytransplantation. Springerplus, 2016;4:5:7.

  18. Sauget M, Verdy S, Slekovec C, Bertrand X, Talon D.Bacterial contamination of organ 2 graft preservationsolution and infection after transplantation. TransplInfect Dis, 2011; 13(4):331–4.

  19. Yansouni CP, Dendukuri N, Liu G, Fernandez M,Frenette C, Paraskevas S, et al. Positive culturesof organ preservation fluid predict postoperativeinfections in solid organ transplantation recipients.Infect Control Hosp Epidemiol, 2012;33(7):672–80.

  20. Yu X, Wang R, Peng W, Huang H, Liu G, Yang Q,et al. Incidence, distribution and clinical relevance ofmicrobial contamination of preservation solution indeceased kidney transplant recipients: a retrospectivecohort study from China. Clin Microbiol Infect, 2019;25(5):595-600.

  21. Corbel A, Ladrière M, Le Berre N, Durin L, RousseauH, Frimat L, Thilly N, Pulcini C. Microbiologicalepidemiology of preservation fluids in transplantedkidney: a nationwide retrospective observationalstudy. Clin Microbiol Infect, 2020;26(4):475-84.

  22. D. Tixier, B. Barrou. Recommandations techniquespour le prélèvement des organes et des tissus surdonneurs en état de mort encéphalique. Agence dela Biomédecine; 2006. Disponible en: https://www.agence-biomedecine.fr/IMG/pdf/recommandationstechniques-concernant-le-donneur-en-etat-de_mortencephalique.pdf




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Rev Nefrol Dial Traspl. 2024;44