2025, Number 2
Progression of AIDS-related Kaposi sarcoma as part of immune reconstitution inflammatory syndrome
Pérez AL, Juárez MP, Ramón CCJ
Language: Spanish
References: 6
Page: 192-194
PDF size: 186.98 Kb.
ABSTRACT
Introduction: Kaposi sarcoma (KS) is a malignant angiomatous tumor of mucocutaneous involvement associated with HIV. It presents with less than 200 CD4 lymphocytes. Clinical case: a 40-year-old HIV-positive man with KS at diagnosis who abandons antiretroviral treatment (ART). Four years later, the patient presented a progression of skin lesions to the thighs and genitals after restarting ART. Conclusion: Immune reconstitution syndrome (IRIS) consists of the paradoxical activation or worsening of latent opportunistic infections while improving the immunological situation. The incidence of KS associated with IRIS is 7%. Treatment consists of maintaining ART and adding chemotherapy in severe cases.REFERENCES
Nyirenda M, Ngongondo M, Kang M, Umbleja T, Krown SE, Godfrey C et al. Early progression and immune reconstitution inflammatory syndrome during treatment of mild-to-moderate Kaposi sarcoma in Sub-Saharan Africa and South America: incidence, long-term outcomes, and effects of early chemotherapy. J Acquir Immune Defic Syndr. 2020; 84 (4): 422-429.