Vázquez GLI, Pizaña DA, Jaramillo SEA, Alba ANV, Sánchez PW

Language: Spanish
References: 27
Page: 609-614
PDF size: 287.37 Kb.

ABSTRACT

Introduction: acute kidney injury (AKI) is a common and serious condition in critically ill patients, with a high prevalence in Intensive Care Units (ICUs) and a significant association with mortality. Current metho ds for diagnosing AKI are based on biochemical markers such as creatinine and urea, as well as urine output. However, these markers have limitations, such as a delayed response to kidney injury and a lack of specificity, which is why cystatin C has been proposed as a potential early biomarker for AKI, making it a more sensitive indicator of kidney function than creatinine. Objective: to compare the diagnostic accuracy of cystatin C against serum creatinine; in the prediction of AKI in critically ill patients admitted to the ICU. Material and methods: a retrospective, observational, descriptive study was carried out, with an analytical and comparative approach. Results: a total of 69 patients were obtained who were adapted to SPSS to perform a multivariate analysis, finding that cystatin C (OR 2.71, 95% CI 1.50-1.84, p = 0.033), and creatinine at 3 days (OR 1.89, 95% CI 1.20-1.96, p = 0.013) were significant predictors of acute kidney injury. Conclusion: cystatin C is a useful biomarker in the early identification of AKI.

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