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Colegio de Medicina Interna de México.

2025, Number 02

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Med Int Mex 2025; 41 (02)

Position of the Mexican Society of Cardiology regarding the indication of fibrates

Pavía LAA, Garnica CJC, Cruz BI, Díaz AA, Lavalle GFJ, Ahumada AM, Zubirán SR, Moreno AAB, Cossío AJE, De los Ríos IMO, Alcocer GMA, López DE, Ezquerra OA, Aldrete VJ, Roque SY

Language: Spanish
References: 158
Page: 78-120
PDF size: 568.60 Kb.


ABSTRACT

Objective: To present the position of the Mexican Society of Cardiology regarding the indication of fibrates in patients with mixed dyslipidemia, based on the best available evidence and consensus among specialists. To provide recommendations for their optimal indication as an adjunct treatment to statins to reduce cardiovascular risk.
Materials and Methods: A review of the evidence according to international standards was performed using Medline, PubMed, and Cochrane databases with specific MeSH terms. The expert group identified 15 relevant clinical questions for discussion in virtual meetings and by consensus using the modified Delphi panel method to define the recommendations included in this review.
Results: Fibrates are indicated for the treatment of patients with isolated hypertriglyceridemia and mixed hyperlipidemia, with type 2 diabetes mellitus or metabolic syndrome, with dyslipidemia and a history of ischemic heart disease, with baseline non-HDL-C levels greater than 200 mg/dL, and with no cardiovascular history; treatment with fibrates is associated with a reduction in the incidence of coronary events and non-fatal myocardial infarction.
Conclusions: Although fibrates have been shown to be useful in various clinical contexts, the recommendations contained herein are not absolute and do not replace the independent clinical judgment of each physician, nor do they take precedence over the individual circumstances of each patient.


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