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2025, Number 3

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Acta Med 2025; 23 (3)

Changes in the inspiratory oxygen fraction 24 hours prior as a predictor of positivity in respiratory multiplex PCR in patients with suspected pneumonia: a case-control study

Martínez FA, Solís AE, Francés FE, Chávez DJ, Esponda PJG

Language: Spanish
References: 15
Page: 254-257
PDF size: 175.91 Kb.


ABSTRACT

Introduction: pneumonia, one of the leading causes of morbidity and mortality globally, highlights the urgency of early antibiotic administration. However, the complexity in quickly identifying the etiological agent often leads to the adoption of empirical treatments, despite advances in diagnostic techniques such as multiplex PCR, which facilitates the effective detection of pathogens and their resistances. Objective: to determine if patients with positive multiplex respiratory PCR had a higher requirement of oxygen 24 hours prior to obtaining the study result. Material and methods: this study explored the relationship between the increase in oxygen need and the positivity of the multiplex respiratory PCR test in hospitalized patients, using a retrospective, cross-sectional, case-control design at Hospital Angeles Pedregal. Results: the study revealed an equitable gender distribution and varied comorbidities among patients, showing significant differences in age and oxygen requirement based on PCR results, without significant differences in hospital stay or leukocyte counts; additionally, smoking was significantly associated with PCR positivity, while mortality, ICU admission, and the need for mechanical ventilation showed no significant associations. Conclusion: the importance of oxygen monitoring as a clinical indicator in diagnosing respiratory infections has been reaffirmed, and an understanding of how comorbidities and lifestyle habits impact the evolution and prognosis of these conditions has been expanded.


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