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2022, Number 3

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Rev Cubana Plant Med 2022; 27 (3)

Lipid and oxidative profile in Wistar rats after administration of lecithin from Glycine max L. Merr (soy)

Cala CL, Cruz VH, Reyes CM, Morris QHJ

Language: Spanish
References: 20
Page:
PDF size: 313.09 Kb.


ABSTRACT

Introduction: Soy lecithin is a dietary supplement with supposed benefits as an antioxidant and lipid-lowering agent.
Objective: To determine the preclinical effect of soy lecithin on the lipid profile and the oxidative state in Wistar rats.
Method: An experimental preclinical pharmacology study was carried out in the Basic Sciences Laboratory of the University of Medical Sciences of Santiago de Cuba and LABEX-CIM, in 2019. Soy lecithin was administered for 30 days, in doses considered as maximum and minimum to two experimental groups of Wistar rats, to be compared with a control group that received regular feeding. Lipid and oxidative profile values were determined and differences were established between the experimental groups using the Kruskal-Wallis test of independent samples, considering the level of significance less than 5%.
Results: The general reduction of the variables estimated as markers of Oxidative Stress can be seen in the administration groups, being more evident in the group of animals that received soy lecithin at the maximum dose. A tendency to stability of its values was observed in catalase in the three groups, with discrete intragroup variations.
Conclusions: Soy lecithin induced a state of oxidative stress associated with increased serum lipid levels in rats, probably related to inflammatory phenomena in the target tissues, which should be corroborated in future research.


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