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2022, Number 3

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Rev Cubana Plant Med 2022; 27 (3)

Evaluation of the biological activity of Moringa oleífera seed oil

Lago AV, León SG, Rodríguez JE

Language: Spanish
References: 33
Page:
PDF size: 433.35 Kb.


ABSTRACT

Introduction: Moringa oleifera has nutritional and pharmacological properties, which could become a nutritional and preventive alternative for diseases. The oil is antioxidant, anti-inflammatory and healing, so the study for use and consumption guarantee its quality and safety.
Objective: To evaluate the biological activity of Moringa seed oil for safe and effective use in humans.
Methods: The plant species used in this work were Moringa oleifera seeds from India. The animals used were supplied by the National Center for the Production of Laboratory Animals (CENPALAB), Havana, Cuba. The diet consisted of a standard diet; for rats CMO 1004 and for rabbits CMO 1400 granules (AlyCo®) (CENPALAB) and chlorinated water for ad libitum consumption.
Results: The acute toxicity tests in Wistar rats, at a dose of 2000 mg/kg did not present toxicity, adjusting the oil to category 5 of the GHS. Skin irritation and eye irritation in albino rabbits were non-irritating. The genotoxic activity of the oil by the micronucleus induction test in mouse bone marrow did not cause toxicity or aneugenic or clastogenic damage on erythropoietic tissue. The healing activity in the mouse epidermis and dermis was similar to Hebermin, however, it did not show a dermoregenerative effect on skin damaged by UVB radiation.
Conclusions: Moringa seed oil does not produce acute oral toxicity in rats, nor does it cause clastogenic - aneugenic damage in vivo. It is considered safe at the doses studied and may be an alternative for wound healing treatment without a dermoregenerative effect. It is anti-inflammatory and prevents the proliferation of microorganisms.


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