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Anales de Otorrinolaringología Mexicana

2025, Number 2

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Otorrinolaringología 2025; 70 (2)

Application of collagenase in patients with hypertrophic scarring following rhinoplasty

Escalante BK, Durán OM, Pineda CF, Sotelo RMT

Language: Spanish
References: 12
Page: 81-89
PDF size: 307.49 Kb.


ABSTRACT

Objective: To evaluate the effectiveness of intralesional collagenase in improving hypertrophic nasal scars, focusing on aesthetics and functionality.
Materials and Methods: Quasi-experimental intersubject pre-posttest design including patients with hypertrophic scars post-rhinoseptoplasty that were classified by scar age: 0-6 months, 7-12 months, and over 12 months. Intralesional collagenase was applied using the blanching technique. Changes in pigmentation, vascularity, and thickness were evaluated using the Vancouver scale, and nasal obstruction was assessed using the NOSE scale, both pre- and post-treatment.
Results: Thirteen patients were included. Recent scars (0-6 months) showed the greatest reductions in pigmentation (7.7%) and thickness (8.2%). Medium-aged scars (7-12 months) had the largest decreases in vascularity (17.8%) and NOSE score improvement (10.8%). Older scars (over 12 months) demonstrated less response, with reductions in pigmentation (5%) and thickness (5.2%).
Conclusions: Intralesional collagenase effectively improves aesthetics and functionality in recent and medium-aged scars, with a reduced impact on older scars. This treatment offers a viable non-surgical alternative for post-rhinoseptoplasty complications.


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