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2025, Number 1

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Med Crit 2025; 39 (1)

Survival analysis according to energy loads in obese patients with respiratory failure due to COVID

González-Castro A, Cuenca-Fito E, Peñasco Y, Dierssen-Soto T, Gómez-Acebo I, Ferrero-Franco R, Ferrer D, Escudero-Acha P, Fajardo A, Rodríguez-Borregán JC

Language: Spanish
References: 20
Page: 25-29
PDF size: 268.99 Kb.


ABSTRACT

Introduction: the influence that the values related to conduction pressure and positive pressure at the end of expiration has on obese patients who required mechanical ventilation during the SARS-CoV-2 pandemic has been little studied. Material and methods: cohort study, longitudinal, analytical. The patients were divided into 4 groups according to the degree of hypoxemia and obesity. The main variables of interest analyzed were driving power and dynamic power. Comparisons of percentages between groups were made using analysis of variance (ANOVA), for the analysis of continuous variables the Kruskal-Wallis test was used. A 28-day survival analysis was performed using the Kaplan-Meier method for the Log-Rank test. Results: a total of 253 patients were analyzed. The group of patients with severe hypoxia and obesity presented the highest mean values of mechanical power (MP): 20.96 J/min (95%CI 18.29-22.84) and driving power: 49.91 (95%CI 38.99-57.67) cmH2O × L/min; the highest mean value of dynamic power was found in the group of patients without severe hypoxemia with obesity: 153.13 (95%CI 129.75-185.95) cmH2O × L/min. In the survival analysis between the four groups, there were no differences in survival at 28 days (Log-Rank test p = 0.44). Conclusion: the dynamic power presented significant differences between the groups of patients according to the presence of the obesity variable in the categorization of the group, without finding significant differences between groups in terms of mortality at 28 days.


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