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2025, Number 2

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Rev Mex Pediatr 2025; 92 (2)

Diabetic ketoacidosis, hypokalemia and supra ST-segment elevation

Quintero-Aguirre E, Galicia-Martínez MÁ, Piña-García LE, López-Rodríguez I
Full text How to cite this article 10.35366/121152

DOI

DOI: 10.35366/121152
URL: https://dx.doi.org/10.35366/121152

Language: Spanish
References: 23
Page: 67-71
PDF size: 360.99 Kb.


Key words:

adolescent, ketoacidosis, diabetes, hypokalemia, electrocardiogram, myocardial infarction.

ABSTRACT

Introduction: ST-segment electrocardiographic changes in patients with diabetic ketoacidosis (DKA) have, to date, only been described in the adult population. Case presentation: a 13-year-old female patient with obesity experienced her first episode of DKA, classified as severe (pH 6.89, HCO3 3.6 mEq/L, blood glucose 510 mg/dL), and presented with marked hypokalemia (1.70 mEq/L). Electrocardiogram (ECG) findings included sinus tachycardia, a peaked T wave, and ST-segment elevation in leads II to VI, without clinical signs of ischemic coronary syndrome. Conclusions: this case appears to be the first report of a pediatric patient with DKA presenting ECG changes suggestive of acute myocardial infarction. In the future, we hope that the presentation of this case will serve to improve the care of similar patients.


REFERENCES

  1. Carrizales-Sepúlveda EF, Vera-Pineda R, Jiménez-Castillo RA, Violante-Cumpa JR, Flores-Ramírez R, Ordaz-Farías A. The heart in diabetic ketoacidosis: a narrative review focusing on the acute cardiac effects and electrocardiographic abnormalities. Am J Med Sci. 2021; 361(6): 690-701.

  2. Atabek ME, Pirgon O, Oran B, Erkul I, Kurtoglu S. Increased cardiac troponin I concentration in diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2004; 17(8): 1077-1082.

  3. Bandyopadhyay D, Devanabanda AR, Tummala R, Chakraborty S, Hajra A, Amgai B et al. Effect of diabetic ketoacidosis on the outcomes of ST-elevation myocardial infarction: An analysis of national inpatient sample. Int J Cardiol Heart Vasc. 2019; 24: 100384. doi: 10.1016/j.ijcha.2019.100384.

  4. Tretjak M, Verovnik F, Vujkovac B, Slemenik-Pusnik C, Noc M. Severe diabetic ketoacidosis associated with acute myocardial necrosis. Diabetes Care. 2003; 26(10): 2959-2960. doi: 10.2337/diacare.26.10.2959.

  5. Master V, Malla G, Rafiullah M, Sandhu HS. Pseudo-myocardial infarction in diabetic ketoacidosis with normokalemia. Endocr Pract. 2023; 29(5 Suppl): S25. doi: 10.1016/j.eprac.2023.03.060.

  6. Hung SC, Chiang CE, Chen JD, Ding PYA. Pseudo–myocardial infarction. Circulation. 2000; 101(25): 2989-2990. doi: 10.1161/01.CIR.101.25.2989.

  7. López-Sendón J, López de Sá E. Nuevos criterios de diagnóstico de infarto de miocardio: orden en el caos. Rev Esp Cardiol. 2001; 54: 669-674. doi: 10.1016/S0300-8932(01)76379-8.

  8. Machado Villarroel L, Olmos Granados HM. Marcadores Biológicos en el diagnóstico del infarto agudo al miocardio. ExpMed [Internet]. 2022; 9(3): 7-13. Disponible en: https://erevistas.uacj.mx/ojs/index.php/expemed/article/view/5368

  9. Suryawanshi SP, Das B, Patnaik AN. Myocardial infarction in children: Two interesting cases. Ann Pediatr Cardiol. 2011; 4(1): 81-83. doi: 10.4103/0974-2069.79633.

  10. Bilici M, Ture M, Balik H. Myocardial infarction in children [Internet]. In: Myocardial infarction. London: IntechOpen; 2019. Disponible en: http://dx.doi.org/10.5772/intechopen.74793

  11. Quintero-Aguirre E, Balbuena-Robles LH, Barrera-Villegas G, Serna D. Dolor precordial en los adolescentes y diagnóstico diferencial de la onda T. Rev Mex Pediatr. 2015; 82(1): 14-17.

  12. Towbin JA, Bricker JT, Garson A Jr. Electrocardiographic criteria for diagnosis of acute myocardial infarction in childhood. Am J Cardiol. 1992; 69(19): 1545-1548.

  13. Burgos LM, Domínguez M, Battioni L, Costabel JP, Trivi M. Cambios electrocardiográficos asociados a hipopotasemia: Alteraciones del segmento ST imitando isquemia miocárdica de múltiples territorios. Rev Chil Cardiol. 2017; 36(3): 244?248. doi: 10.4067/s0718-85602017000300244.

  14. Ziakas A, Basagiannis C, Stiliadis I. Pseudoinfarction pattern in a patient with hyperkalemia, diabetic ketoacidosis and normal coronary vessels: a case report. J Med Case Rep. 2010; 4: 115. doi: 10.1186/1752-1947-4-115.

  15. Glaser N, Fritsch M, Priyambada L, Rewers A, Cherubini V, Estrada S et al. ISPAD clinical practice consensus guidelines 2022: Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatr Diabetes. 2022; 23(7): 835-856. doi: 10.1111/pedi.13406.

  16. Misra S, Aguilar-Salinas CA, Chikowore T, Konradsen F, Ma RCW, Mbau L et al. The case for precision medicine in the prevention, diagnosis, and treatment of cardiometabolic diseases in low-income and middle-income countries. Lancet Diabetes Endocrinol. 2023; 11(11): 836-847.

  17. Raj M. Obesity and cardiovascular risk in children and adolescents. Indian J Endocrinol Metab. 2012; 16(1): 13-19. doi: 10.4103/2230-8210.91176.

  18. Vanlancker T, Schaubroeck E, Vyncke K, Cadenas-Sanchez C, Breidenassel C, González-Gross M et al. Comparison of definitions for the metabolic syndrome in adolescents. The HELENA study. Eur J Pediatr. 2017; 176(2): 241-252. doi: 10.1007/s00431-016-2831-6.

  19. Sharma E, Dahal S, Sharma P, Ghimire DK, Dahal S. A case of pseudoinfarction pattern in diabetic ketoacidosis: a diagnostic and therapeutic dilemma. Cardiol Res. 2018; 9(4): 250-252. doi: 10.14740/cr747w.

  20. Aksakal E, Duman H, Ulus T, Bayram E. Acute inferior pseudoinfarction pattern in a patient with normokalemia and diabetic ketoacidosis. Am J Emerg Med. 2009; 27(2): 251.e3-5. doi: 10.1016/j.ajem.2008.06.024.

  21. Nunes JP. Pseudo myocardial infarction - a condition in need to be redefined? Med Hypotheses. 2010; 74(2): 219-221. doi: 10.1016/j.mehy.2009.09.041.

  22. Egil O, Sap F, Selver Eklioglu B, Oflaz MB, Atabek ME, Baysal T. First evaluation of P dispersion and Tp-e parameters in electrocardiograms of children with diabetic ketoacidosis. J Clin Res Pediatr Endocrinol. 2023; 14(1): 37-45. doi: 10.4274/jcrpe.galenos.2021.2021.0165.

  23. Atabek ME, Pirgon O, Oran B, Erkul I, Kurtoglu S. Increased cardiac troponin I concentration in diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2004; 17(8): 1077-1082. doi: 10.1515/jpem.2004.17.8.1077.




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Rev Mex Pediatr. 2025;92