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2025, Number 5

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Acta Med 2025; 23 (5)

Effect of tranexamic acid in reducing total blood loss in total knee arthroplasty without application of ischemia

Morán CSL, German CI, Mejía TG

Language: Spanish
References: 26
Page: 418-422
PDF size: 223.91 Kb.


ABSTRACT

Introduction: total knee arthroplasty generates significant bleeding, and tranexamic acid, an antifibrinolytic agent, is an option to safely and effectively reduce the number of transfusions to prevent bleeding. Objective: evaluation of the effect of tranexamic acid in reducing total blood loss in total knee arthroplasty without ischemia. Material and methods: a prospective study of patients undergoing total knee arthroplasty under neuraxial anesthesia was divided into two groups: group A, in which tranexamic acid was used with a tourniquet, and group B, in which tranexamic acid was used without a tourniquet. Bleeding and the need for blood transfusion were assessed. Results: 30 patients were included in each group. No statistically significant differences were found between the groups in their demographic characteristics. The difference in initial and final Hct was 44.4 ± 2.7% in group A vs 44.5 ± 3.6% in group B. Total blood loss was 465.8 mL in group A vs 494.1 mL in group B, without significant differences (p = 0.652). Conclusion: tranexamic acid in total knee arthroplasty reduces blood loss similarly to mechanical ischemia but without adverse effects.


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