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2025, Number 3

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Cir Gen 2025; 47 (3)

Portal vein thrombosis associated with splenectomy

Avalos HA, Chávez BLA, Maldonado RRA, Cantellano MS, Ortiz HV

Language: Spanish
References: 24
Page: 166-173
PDF size: 346.48 Kb.


ABSTRACT

Introduction: portal vein thrombosis is defined as the formation of one or more clots within the portal vein or its main collaterals. Depending on its severity, it can lead to a wide range of clinical manifestations as well as life-threatening events. Objective: to determine the risk factors for developing portal vein thrombosis in patients undergoing splenectomy. Material and methods: this was an observational, longitudinal, analytical, nested case-control cohort study of patients undergoing splenectomy. In all cases, abdominal Doppler ultrasound and/or contrast-enhanced abdominal tomography were performed 14-21 days postoperatively to assess the presence or absence of thrombosis. Results: twenty-four patients were included. Most splenectomies were performed laparoscopically, with a conversion rate of 12.5%, with autoimmune thrombocytopenia being the main indication. Portal vein thrombosis occurred in two patients, both chronic users of steroids and mycophenolate mofetil. Conclusions: the incidence of portal vein thrombosis was similar to that reported in the literature, and only 50% of patients developed symptoms. We found a statistically significant association between mycophenolate mofetil use and portal vein thrombosis and between bleeding and portal vein thrombosis; however, these results should be viewed with caution.


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