2026, Number 1
<< Back Next >>
Acta Med 2026; 24 (1)
Predictive factors for thrombosis in the splanchnic territory secondary to acute pancreatitis: a case-control study
Francés FE, Taracena PS, Rodríguez WFL, Díaz GEJ
Language: Spanish
References: 13
Page: 21-25
PDF size: 263.22 Kb.
ABSTRACT
Introduction: acute pancreatitis is one of the most common conditions affecting the digestive tract, and the information regarding the relationship between acute pancreatitis and splanchnic vein thrombosis is limited. This study aims to identify factors contributing to the development of splanchnic vein thrombosis in patients with acute pancreatitis.
Objective: a retrospective documentation of cases involving patients with splanchnic vein thrombosis and acute pancreatitis was performed. These cases were compared with patients without thrombosis to determine factors that may contribute to a prothrombotic state in patients with acute pancreatitis.
Material and methods: this is a descriptive, retrospective, and analytical case-control study (2016-2023). Cases were defined as patients with splanchnic vein thrombosis, while controls were those without thrombosis. After identifying patients through imaging records, clinical files were reviewed to obtain variable data.
Results: a total of 280 patients with acute pancreatitis were studied, of whom 13 patients (4.6%) developed splanchnic vein thrombosis, with an average age of 47 years. It was observed that neoplastic-origin pancreatitis was exclusively associated with thrombosis, while biliary-origin pancreatitis was not (p = 0.005). Overweight/obesity significantly increased the risk of thrombosis (p = 0.013), and neoplasms showed a marginal association (p = 0.053).
Conclusion: the cause of acute pancreatitis and BMI are important factors in determining the risk of thrombosis in the splanchnic circulation; both a neoplastic etiology and a higher BMI are associated with an increased risk of thrombosis.
REFERENCES
Leppaniemi A, Tolonen M, Tarasconi A, Segovia-Lohse H, Gamberini E, Kirkpatrick AW et al. WSES guidelines for the management of severe acute pancreatitis. World Journal of Emergency Surgery. 2019; 14 (1): 1-20.
Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013; 13 (4 Suppl 2): e1-15.
ASGE Standards of Practice Committee; Chandrasekhara V, Chathadi KV, Acosta RD, Decker GA, Early DS et al. The role of endoscopy in benign pancreatic disease. Gastrointest Endosc. 2015; 82 (2): 203-214.
Koonarat A, Rattarittamrong E, Tantiworawit A, Rattanathammethee T, Hantrakool S, Chai-Adisaksopha C et al. Clinical characteristics, risk factors, and outcomes of usual and unusual site venous thromboembolism. Blood Coagul Fibrinolysis. 2018; 29 (1): 12-18.
Shatzel JJ, O'Donnell M, Olson SR, Kearney MR, Daughety MM, Hum J et al. Venous thrombosis in unusual sites: a practical review for the hematologist. Eur J Haematol. 2019; 102 (1): 53-62.
Anis FS, Adiamah A, Lobo DN, Sanyal S. Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2022; 37 (3): 446-454.
Qi X, De Stefano V, Senzolo M, Xu H, Mancuso A. Splanchnic vein thrombosis: etiology, diagnosis, and treatment. Gastroenterol Res Pract. 2015; 2015: 506136.
Valentín MAB, Cortés VJJ, Ortega LR, García NCJ, Madrid MMC, González SJ. Trombosis esplenoportal: revisión en imágenes. SERaM.
Ordieres-Ortega L, Demelo-Rodríguez P, Galeano-Valle F, Kremers BMM, Ten Cate-Hoek AJ, Ten Cate H. Predictive value of D-dimer testing for the diagnosis of venous thrombosis in unusual locations: a systematic review. Thromb Res. 2020; 189: 5-12.
Isfordink CJ, Dekker D, Monkelbaan JF. Clinical value of serum lactate measurement in diagnosing acute mesenteric ischaemia. Neth J Med. 2018; 76 (2): 60-64.
Toqué L, Hamy A, Hamel JF, Cesbron E, Hulo P, Robert SC et al. Predictive factors of splanchnic vein thrombosis in acute pancreatitis: a 6-year single-center experience. J Dig Dis. 2015; 16 (12): 734-740.
Roach RE, Cannegieter SC, Lijfering WM. Differential risks in men and women for first and recurrent venous thrombosis: the role of genes and environment. J Thromb Haemost. 2014; 12: 1593-1600.
Severinsen MT, Kristensen SR, Johnsen SP, Dethlefsen C, Tjonneland A, Overvad K. Smoking and venous thromboembolism: a Danish follow-up study. J Thromb Haemost. 2009; 7: 1297-1303.