Cabrera AI, Díaz de la Fe A, Robinson AMÁ, García LY, Báez MM, Grass FD

Language: Spanish
References: 26
Page:
PDF size: 396.93 Kb.

ABSTRACT

Introduction: The Multiple Sclerosis (MS) it is an inflammatory chronic and demyelinating disease of the central nervous system, in which is known that from their initial phase it can show alterations of some cognitive functions. The present work approaches some of the possible neuropsychological alterations observed in the pediatric form of MS." To describe the profile of patient pediatric with EM and their possible association with the clinical disability evaluated by the scale of Kurzke, the images of magnetic resonance (MRI) and the neurophysiological technics.
Methods: The four presented cases were assisted at the International Center of Neurological Restoration, with diagnosis of MS relapse-remission. The study included the analyses of attention functions, memory, language, visospacial abilities and frontal executive functions, as well as their possible association with the lesions observed by magnetic resonance and the alterations in the sensitive evoked potentials.
Results: All the patients presented alterations at cognitive function, with major affectation of memory functions and the frontal executive functions, besides others alterations in the neurophysiological studies and the magnetic resonance.
Conclusions: The highest psychic functions were affected in all patients, without apparent relationship with the localization of the lesions observed at MRI, and with the degree of functional affectation from the evaluation neurophysiological, still in the cases with mild-moderate disability.

REFERENCES

1. Boiko A, Vorobeychik G, Paty D, et al. Early onset multiple sclerosis: A longitudinal study. Neurology 2002; 59: 1006–1010.

2. Venkateswaran S and Banwell B. Pediatric multiple sclerosis. Neurologist 2010; 16: 92–105. 6. Banwell B, Krupp L, Kennedy J, et al. linical

3. Simone IL, Carrara D, Tortorella C, et al. Course and prognosis in early-onset MS: Comparison with adult onset forms. Neurology 2002; 59: 1922–1928.

4. Cole GF, Auchterlonie LA and Best PV. Very early onset multiple sclerosis. Dev Med Child Neurol 1995; 37: 667–672.

5. Features and viral serologies in children with multiple sclerosis: A multinational observational study. Lancet Neurol 2007; 6: 773–781.

6. Venkateswaran S and Banwell B. Pediatric multiple sclerosis. Neurologist 2010; 16: 92–105.

7. Scaioli V, Rumi V, Cimino C, and Angelini L. Childhood multiple sclerosis (MS): multimodal evoked potentials (EP) and magnetic resonance imaging (MRI) comparative study. Neuropediatrics 1991; 22:15-23.

8. Pohl D, Rostasy K, Treiber-Held S, Brockmann K, Gartner J, Hanefeld F. Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials. J Pediatric 2006; 149:125-7.

9. Pohl D, Rostasy K, Gartner J, Hanefeld F. Treatment of early onset multiple sclerosis

10. Mikaeloff Y, Adamsbaum C, Husson B, et al. MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain 2004; 127:1942-7.

11. Hahn CD, Shroff MM, Blaser S, Banwell BL. MRI criteria for multiple sclerosis: evaluation in a pediatric cohort. Neurology 2004; 62:806-8.

12. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50:121-7.

13. Krupp LB, Banwell B, Tenembaum S. Consensus definitions proposed

14. for pediatric multiple sclerosis and related disorders. Neurology.2007; 68:S7-12.

15. Kuhle J, Disanto G, Dobson R, et al. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicenter study. Mult Scler. 2015; 21:1013-1024.

16. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983; 33:1444-1452.

17. Julian L, Serafin D, Charvet L, et al. Cognitive impairment occurs

18. in children and adolescents with multiple sclerosis: results from a United States network. J Child Neurol. 2013; 28:102-107.

19. MacAllister WS, Belman AL, Milazzo M, et al. Cognitive functioning in children and adolescents with multiple sclerosis. Neurology. 2005; 64:1422–1425. [PubMed: 15851734]

20. Fuentes A, Collins DL, García-Lorenzo D, et al. Memory performance and normalized regional brain volumes in patients with pediatric-onset multiple sclerosis. J Int Neuropsychology Soc. 2012; 18:471–480. [PubMed: 22321690]

21. Suppiej A, Cainelli E. Cognitive dysfunction in pediatric multiple sclerosis. Neuropsychiatric Disease and Treatment. 2014:10 1385–1392.

22. Amato MP, Goretti B, Ghezzi A, et al. Cognitive and psychosocial features of childhood and juvenile MS. Neurology. 2008; 70:1891–1897. [PubMed: 18474844]

23. Callen JA, Shroff MM, Branson HM, Lotze T, Li DK, Stephens D, Banwell BL. MRI in the diagnosis of pediatric multiple sclerosis. Neurology 2009; 72:961-7.

24. Scaioli V, Rumi V, Cimino C, Angelini L. Childhood multiple sclerosis (MS): multimodal evoked potentials (EP) and magnetic resonance imaging (MRI) comparative study. Neuropediatrics 1991; 22:15-23.

25. Pohl D, Rostasy K, Treiber-Held S, Brockmann K, Gartner J, Hanefeld F. Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials. J Pediatric 2006; 149:125-7.

26. Hadjigeorgiou I, Villar C, Weygaert V, Hernández MA, Mirallave A Pescador3, Arnau A. Esclerosis Múltiple pediátrica. Revista española de Esclerosis Múltiple. No 25. marzo 2013.