medigraphic.com
ISSN 1995-9427 (Print)

2023, Number 1

<< Back Next >>

Invest Medicoquir 2023; 15 (1)

Covid-19 en pacientes con trasplante hepático

Samada SM, Valenzuela AK, Moret VS

Language: Spanish
References: 14
Page:
PDF size: 321.09 Kb.


ABSTRACT

Introduction. Patients with liver transplant, due to the use of immunosuppressants and the comorbidities they present, may have a higher risk of presenting Covid-19, but its incidence and evolution are still topics of debate.
Objective. To determine the behavior of Covid-19 in liver transplant patients.
Methods. An observational, prospective and longitudinal study was carried out in 17 liver transplant patients from the Surgical Medical Research Center, who acquired Covid-19 between March 2020 and February 2022. Patients who tested positive for SARS-CoV-2 (through the nucleic acid test) were considered COVID-19 positive. The main variables of the study were: age, sex, clinical picture, comorbidities and mortality.
Results. Of 69 patients with liver transplant, 17 (24.6%) had Covid-19, 9 (52.9%) were female and 58.8% were under 60 years of age. Regarding the clinical picture, 9 (52.9%) patients presented the uncomplicated form of the disease, of the comorbidities 94.1% had arterial hypertension, 23 % diabetes mellitus and 17 % renal dysfunction. Mortality from Covid-19 was 11.7 %, the two patients who died had arterial hypertension, previous renal dysfunction, and were older than 60 years.
Conclusions. The behavior of Covid-19 in liver transplant patients could be similar to the general population, with great influence of age and comorbidities on mortality.


REFERENCES

  1. Manejo clínico de la COVID-19, Orientaciones evolutivas 25 de enero de 2021. Organización Mundial de la Salud (OMS): WHO/2019-nCoV/clinical/2021.1

  2. Loinaz-SegurolaC, Marcacuzco-Quinto A, Fernández-Ruiz M. Coronavirus disease 2019 in liver transplant patients: Clinical and therapeutic aspects. World J Hepatol 2021 October 27; 13(10): 1299-1315. DOI: 10.4254/wjh.v13.i10.1299

  3. Pérez-González B, Thomas-Lora FC, Hoyo I, Flores-García NC, Rodríguez- Aguilar EF, Páez-Zayas VM , et al. Trasplante hepático durante la pandemia del SARS-CoV-2 (COVID-19). Revisión de la literatura. Cir Cir. 2021;89(2):269-274. DOI: 10.24875/CIRU.20000994

  4. Kulkarni AV, Vardhan Tevethia H, Premkumar M, Arab JP, Candia R, Kumar K, et al. Impact of COVID-19 on liver transplant recipients. A systematic review and meta-analysis. EClinicalMedicine 38 (2021) 101025. https://doi.org/10.1016/j.eclinm.2021.101025 2589-5370

  5. Colmenero J, Rodríguez-Perálvarez M, Salcedo M, Arias-Milla A, Muñoz- Serrano A, Graus J, et al. Epidemiological pattern, incidence and outcomes of COVID-19 in liver transplant patients. J Hepatol. 2021;74:148-55. DOI: 10.1016/j.jhep.2020.07.040]

  6. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects adopted by the 59th WMA General Assembly. Seoul. October 2008.

  7. León JL, Calderón M y Gutiérrez AR. Análisis de mortalidad y comorbilidad por Covid-19 en Cuba. Revista Cubana de Medicina. 2021(Abril-Jun);60(2):e2117

  8. Dumortier J , Duvoux C, Roux O , Altieri M , Barraude H, Besch C, et al. Covid- 19 in liver transplant recipients: the French SOT COVID registry. Clinics and Research in Hepatology and Gastroenterology 45 (2021) 101639. https://doi.org/10.1016/j.clinre.2021.101639

  9. Belli LS, Fondevila C, Cortesi PA, Conti S, Karam V, Adam R, et al. ELITA-ELTR COVID-19 Registry. Protective Role of Tacrolimus, Deleterious Role of Age and Comorbidities in Liver Transplant Recipients With Covid-19: Results From the ELITA/ELTR Multicenter European Study. Gastroenterology 2021; 160: 1151- 1163.e3. DOI: 10.1053/j.gastro.2020.11.045

  10. Verma A, Khorsandi SE, Dolcet A, Prachalias A, Suddle A, Heaton N, Jassem W. Low prevalence and disease severity of COVID-19 in post-liver transplant recipients-A single centre experience. Liver Int 2020; 40: 1972-76. DOI: 10.1111/liv.14552

  11. Pérez MR, Gómez JJ, Dieguez RA. Características clínico-epidemiológicas de la COVID-19. Rev haban cienc méd [Internet]. 2020; 19(2):e_3254. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3254/250

  12. Zheng Z, Peng F, XuB ,Zhao J, Liu H, Peng J, et al. Risk factors of critical& mortal COVID-19 cases: a systematic literature review and meta-analysis. J Infect 2020;81(2):e16–25. DOI: 10.1016/j.jinf.2020.04.021

  13. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney diseases associated with in-hospital death of patients with COVID-19. Kidney Int 2020;97(5):829–38. DOI: 10.1016/j.kint.2020.03.005

  14. Webb GJ, Marjot T, Cook JA, Aloman C, Armstrong MJ, Brenner EJ, et al. Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study. Lancet Gastroenterol Hepatol. 2020;5:1008-16. DOI: 10.1016/S2468-1253(20)30271-5




2020     |     www.medigraphic.com