2023, Number 1
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Invest Medicoquir 2023; 15 (1)
Extrapontine myelinolysis
Jordán GJA, Miñoso AY, Piñera MJ, Abdo CA, Marrero MM, Sánchez GY, Nerey A
Language: Spanish
References: 11
Page:
PDF size: 139.04 Kb.
ABSTRACT
Extrapontine myelinolysis is a rare entity that is related to sodium fluctuations, mainly hyponatremia,
although it is also linked to other metabolic conditions such as diabetes mellitus. We present the case of a
48-year-old woman who suffers from diabetes insipidus treated with adiuretin, which was temporarily suspended and presented hypernatremia that was treated; During this metabolic correction process, he
presented a picture of obtundation associated with flaccid quadriparesis. Magnetic resonance imaging was
performed with 1.5 Tesla Siemens equipment, observing hyperintense lesions with a demyelinating
appearance on T2 and FLAIR sequences at the level of the body and splenium of the corpus callosum and
the base nuclei. The clinical evolution of the patient is described and the pathophysiology of this entity is
discussed.
REFERENCES
R.J. Martin. Central pontine and extrapontine myelinolysis: the osmotic demyelination syndrome.J Neurol Neurosurg Psychiatry 2004;75 (Suppl 3): iii22-8.
Guerrero WR, Dababneh H, Nadeau SE. Hemiparesis, encephalopathy, and extrapontine osmoticmyelinolysis in the setting of hyperosmolar hyperglycemia. J Clin Neurosci 2013; 20: 894-896.
Mayner Tresol Gabriel, l, Reyna Villasmil Eduardo. Mielinolisis central pontina comocomplicación de hiperemesis gravidica.
Madinaveitia Turcott Jaime, Fraind Maya Gabriel, Laventman Grimberg Jaime. Mielinolisiscentral y periférica de la protuberancia: presentación de un caso y revisión de la literature. Rev.Fac. Med. (Méx.) vol.57 no.2 Ciudad de México mar./abr. 2014.
Adams RD, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed diseaseoccurring in alcoholic and malnourished patients. Arch Neurol Psychiatry 1959; 81:154-172.
D.O ,Beraldo,S.B. C.P..Duarte y colb .Pontine Myelinolisis Caused by HipovolemicHypernatremia.Hindawi Informe de caso en nefrologia. Volumen 2020 ID4979098. Sep 2020.1.
Villalba Sanchez R, Roque Ajuacho J,Pedraza Grijalva R,Diaz aguilar R, Villada Mena M.Mielolinisextrapontina en paciente con hypernatremia grave en la UCI. Revista de Sanidad Miltar Vol 66Num 6. Noviembre-Diciembre 2012.
Lien YH, Shapiro JI, Chan L. Study of brain electrolytes and organic os molytes during correctionof chronic hyponatremia: implications for the pathogenesis of central pontine myelinolysis. J ClinInvest 1991; 88: 303-9.
Gamarra Aviles E. A.Guazzaroni N, Bursa L.A. Sindrome de enclaustramiento secundario adesmielinizacion osmótica. Importancia de la resonancia magnética. Revista argentina deradiología Vol. 82, num. 1, pp 42-44, 2018.
López-Sendón Moreno J, Vera Lechuga R, Estévez Santé S, Navacerrada Barrero FJ, Corral CorralI. Mielinolisis central pontina y extrapontina: cuadro clínico, resonancia magnética cerebral yevolución en 13 pacientes. Neurología. 2009;24(3):165-69.
Fernández Cue L, Miranda Hernández J, Gómez Viera N. Valhuerdi Porto C. Desmielinizaciónosmótica pontina y extrapontina durante un puerperio complicado. Rev cubana med vol.57 no.3Ciudad de la Habana jul.-set. 2018.