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2025, Number 3

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Rev Med UAS 2025; 15 (3)

Primary adenosquamous carcinoma of the colon, an uncommon variant: a case report

Fuentes-Valenzuela M, López-López HA, Mantar-Alcantar N, López-Moreno IN, Martínez-Félix JI, Ríos-Burgueño, ER
Full text How to cite this article

Language: Spanish
References: 14
Page: 144-148
PDF size: 207.56 Kb.


Key words:

Adenosquamous carcinoma, right colon, mixed neoplasm, lymph node metastasis, surgical resection.

ABSTRACT

Adenosquamous carcinoma of the colon is a rare malignancy composed of both glandular and squamous malignant components, with more aggressive clinical behavior and poorer prognosis compared to conventional adenocarcinoma. We report the case of a 76-yearold female presenting with abdominal pain and hematochezia, in whom an infiltrative cecal mass was identified. She underwent extended right hemicolectomy, and histopathological analysis confirmed a moderately to poorly differentiated adenosquamous carcinoma. This advanced presentation illustrates the aggressive nature of the disease. Given its rarity, there are no standardized treatment protocols, although surgical resection with negative margins remains the cornerstone of therapy. This case contributes to the clinical and morphological understanding of colonic adenosquamous carcinoma and underscores the need for more evidence to guide its diagnosis and management.


REFERENCES

  1. Cagir B, Nagy MW, Topham A, Rakinic J,Fry RD. Adenosquamous carcinoma of thecolon, rectum, and anus: epidemiology, distribution,and survival characteristics. DisColon Rectum. 1999;42(2):258–63.

  2. Masoomi H, Ziogas A, Lin BS, Barleben A,Mills S, Stamos MJ, et al. Population-basedevaluation of adenosquamous carcinoma ofthe colon and rectum. Dis Colon Rectum.2012;55(5):509–14.

  3. Frizelle FA, Hobday KS, Batts KP, Nelson H.Adenosquamous and squamous carcinomaof the colon and upper rectum: a clinical andhistopathologic study. Dis Colon Rectum.2001;44(3):341–6.

  4. Petrelli NJ, Valle AA, Weber TK, Rodriguez-Bigas M. Adenosquamous carcinoma of thecolon and rectum. Dis Colon Rectum. 1996;39(11):1265–8.

  5. Abdalla MI, Cornish C, Taboada S, KothariS, Doshi R, Kothari TH, et al. Adenosquamouscarcinoma of the cecum: a rare but aggressiveform of colonic neoplasia. FamMed Med Sci Res. 2014;3(4):142.doi:10.4172/2327-4972.1000142

  6. Gjeorgjievski M, Purohit T, Amin M, Patel A.Primary adenosquamous carcinoma of thececum: a rare entity. Am J Gastroenterol.2015;110(Suppl 1):S162.

  7. Toumi O, Hamida B, Njima M, Bouchrika A,Ammar H, Daldoul A, et al. Adenosquamouscarcinoma of the right colon: a case reportand review of the literature. Int J Surg CaseRep. 2018; 53:310–3.doi:10.1016/j.ijscr.2018.07.001

  8. World Health Organization. WHO Classificationof Tumours Editorial Board. DigestiveSystem Tumours. 5th ed. Lyon (France):IARC; 2019. (WHO Classification of Tumoursseries, vol. 1).

  9. Sawicki T, Ruszkowska M, Danielewicz A,Niedźwiedzka E, Arłukowicz T, PrzybyłowiczKE. A Review of Colorectal Cancer in Termsof Epidemiology, Risk Factors, Development,Symptoms and Diagnosis. Cancers.2021;13(9):2025.

  10. Goldblum JR, Lamps LW, McKenney JK.Rosai and Ackerman's Surgical PathologyE-Book: Elsevier; 2017.

  11. The International Agency for Research onCancer (IARC). Global Cancer Observatory.gco.iarc.fr. 2022. Available from:https://gco.iarc.fr/en

  12. Lu SB, Ge FS, Liu C, Hua YW. Adenosquamouscarcinoma of sigmoid colon in an adolescent:A case report and literature review.Asian J Surg. 2022;45(4):1055-6.

  13. Di Prete M, Baciorri F, Franceschilli M,Bagaglini G, Sica G, Doldo E, et al.Adenosquamous carcinoma of the right colonwith diffuse signet-ring mucinous component.Clin J Gastroenterol. 2020;13(4):555-9.

  14. Khan AH, Gao X, Goffredo P, Kahl AR, UtriaAF, Charlton ME, et al. Presentation, treatment,and prognosis of colorectaladenosquamous carcinoma: A contemporaryanalysis of the surveillance, epidemiology,and end results database. Am J Surg.2022;223(5):957-62.




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Rev Med UAS. 2025;15