Sánchez-Castro DM, Ruiz-de la Cruz KA, Ruiz-Barraza RA, Romo-García E, Meza-Anguiano A

Language: Spanish
References: 8
Page: 149-153
PDF size: 361.38 Kb.

ABSTRACT

Background: Astrocytic hamartoma is a benign glial neoplasm commonly found in pediatric or adolescent patients. In more than half of the cases, it is associated with hereditary systemic syndromes, the most common being tuberous sclerosis. Its visual impact de-pends on the location, and although many lesions are asymptomatic, some can develop significant complications. Clinical case: A 10-year-old female was brought to the clinic for visual impairment at school. Ophthalmologic examination identified a multilobulated lesion in the peripheral retina of the right eye, yellowish in appearance and elevated. Multimodal imaging studies confirmed findings compatible with a type III astrocytic hamartoma. A multidisciplinary evaluation ruled out association with tuberous sclerosis complex or other systemic phakomatoses. Conclusion: The discovery of a retinal astrocytic hamartoma should prompt a comprehensive search for systemic diseases. Multimodal imaging studies are essential for the diagnosis and characterization of the neoplasm. This case emphasizes the importance of an interdisciplinary approach and close follow-up in patients with atypical retinal neoplasms.

REFERENCES

1. Northrup H, Aronow ME, Bebin EM, Bissler JJ, Darling TN, de Vries PJ, et al. Updated international tuberous sclerosis complex di-agnostic criteria and surveillance and man-agement recommendations. Pediatr Neurol. 2021;123:50–66.

2. Rowley SA, O'Callaghan FJ, Osborne JP. Ophthalmic manifestations of tuberous scle-rosis: a population based study. Br J Oph-thalmol. 2001;85(4):420–3.

3. Shields CL, Benevides R, Materin MA, Shields JA. Optical coherence tomography of retinal astrocytic hamartoma in 15 cases. Ophthalmology. 2006;113(9):1553–7.

4. Pichi F, Massaro D, Serafino M, Carrai P, Giuliari GP, Shields CL, et al. Retinal astro-cytic hamartoma: optical coherence tomog-raphy classification and correlation with tu-berous sclerosis complex. Retina. 2016;36(6):1199–208.

5. Kroll AJ, Ricker DP, Robb RM, Albert DM. Vitreous hemorrhage complicating retinal astrocytic hamartoma. Surv Ophthalmol. 1981;26(1):31–8.

6. Domínguez AS. Hamartoma astrocítico retiniano: manifestación ocular de esclerosis tuberosa (enfermedad de Bourneville). Rev Mex Oftalmol. 2016;90(4):207–8.

7. Sherman SD, Schechet SA, Shapiro MJ, Blair MP. A case of a combined hamartoma of the retina and RPE concurrently found in the same eye as peripheral astrocytic hamartomas. J VitreoRetin Dis. 2019;3(5):399–402.

8. Silva RP, Alencar LD, Moreira-Neto CA. Hamartoma astrocítico da retina versus os-teoma de coroide: um caso interessante. eOftalmo. 2018;4(3):137–42.