medigraphic.com
ISSN 2683-1678 (Print)
Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2025, Number 4

<< Back Next >>

Rev Latin Infect Pediatr 2025; 38 (4)

Congenital cytomegalovirus: from clinical presentation to diagnosis with negative specific IgM. Apropos of a case report

Arenas CEJ, Velandia FNL, Venegas MME

Language: Spanish
References: 9
Page: 173-176
PDF size: 380.11 Kb.


ABSTRACT

Congenital cytomegalovirus (CMV) can cause serious complications in newborns, especially in the central nervous system. Early diagnosis is crucial for initiating timely treatment and reduce the risk of long-term complications. This report presents a case of congenital CMV infection in a full-term newborn for whom maternal serology did not include CMV data and for whom specific IgM was negative. The diagnosis was confirmed by detection of viral DNA in the urine using PCR.


REFERENCES

  1. Lawrence SM, Goshia T, Sinha M, Fraley SI, Williams M. Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection. Pediatr Res. 2024; 95 (2): 532-542. doi: 10.1038/s41390-023-02957-9.

  2. Cofre F, Delpiano L, Labraña Y, Reyes A, Sandoval A, Izquierdo G. Síndrome de TORCH: enfoque racional del diagnóstico y tratamiento pre y post natal. Recomendaciones del Comité Consultivo de Infecciones Neonatales Sociedad Chilena de Infectología, 2016. Rev Chil Infectol. 2016; 33 (2): 191-216. doi: 10.4067/S0716-10182016000200010.

  3. Grazia M, Zavattoni M, Baldanti F, Sarasini A, Paolucci S, Gerna G. Diagnostic and prognostic value of human cytomegalovirus load and IgM antibody in blood of congenitally infected newborns. J Clin Virol. 1999; 14 (1): 57-66. doi: 10.1016/S1386-6532(99)00016-5.

  4. Gerna G, Fornara C, Furione M, Lilleri D. Congenital human Cytomegalovirus infection: a narrative review of maternal immune response and diagnosis in view of the development of a vaccine and prevention of primary and non-primary infections in pregnancy. Microorganisms. 2021; 9 (8): 1749. doi: 10.3390/microorganisms9081749.

  5. Ssentongo P, Hehnly C, Birungi P, Roach MA, Spady J, Fronterre C et al. Congenital cytomegalovirus infection burden and epidemiologic risk factors in countries with universal screening: a systematic review and meta-analysis. JAMA Netw Open. 2021; 4 (8): e2120736. doi: 10.1001/jamanetworkopen.2021.20736.

  6. Rico A, Dollard SC, Valencia D, Corchuelo S, Tong VT, Laiton-Donato K et al. Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia. J Med Virol. 2021; 93 (11): 6393-6397. doi: 10.1002/jmv.26815.

  7. Society for Maternal-Fetal Medicine (SMFM), Hughes BL, Gyamfi-Bannerman C. Diagnosis and antenatal management of congenital cytomegalovirus infection. Am J Obstet Gynecol. 2016; 214 (6): B5-B11. doi: 10.1016/j.ajog.2016.02.042.

  8. Ohyama S, Fujioka K, Fukushima S, Abe S, Ashina M, Ikuta T et al. Diagnostic value of Cytomegalovirus IgM antibodies at birth in PCR-confirmed congenital Cytomegalovirus infection. Int J Mol Sci. 2019; 20 (13): 3239. doi: 10.3390/ijms20133239.

  9. Nelson CT, Istas AS, Wilkerson MK, Demmler GJ. PCR detection of Cytomegalovirus DNA in serum as a diagnostic test for congenital Cytomegalovirus infection. J Clin Microbiol. 1995; 33 (12): 3317-3318. doi: 10.1128/jcm.33.12.3317-3318.1995.




2020     |     www.medigraphic.com