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Órgano de difusión científica de la Asociación Nefrológica de Buenos Aires

2025, Number 4

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Rev Nefrol Dial Traspl 2025; 45 (4)

From suspected lymphoproliferative disease to Epstein-Barr virus and human herpesvirus type 6 infection in a pediatric kidney transplant patient

Pussetto B, Groppo MS, Vozza ML

Language: Spanish
References: 8
Page: 201-204
PDF size: 221.26 Kb.


ABSTRACT

Post-transplant lymphoproliferative disease (PTLD) is the most common malignancy after solid organ transplantation. Its incidence varies by allograft type, ranging from 1% to 3% in pediatric kidney transplant recipients. PTLD is associated with Epstein-Barr virus (EBV) infection, which induces B-cell proliferation, giving rise to lymphoid tumors. In children, it usually appears within the first two years post-transplant as a rare complication, and the definitive diagnosis is based on histopathological findings. We report the case of a 6-year-old boy who, three months after kidney transplantation, presented with fever and persistent mouth ulcers. Suspecting PTLD, an oral biopsy was performed, confirming EBV and human herpesvirus 6 (HHV-6) infection with negative viral loads in the blood. Immunosuppressive therapy, gamma globulin, and ganciclovir were indicated, with a good clinical response.


REFERENCES

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