Medina HL, Guevara RM, Hernández OMO, Bosch RBB

Language: Spanish
References: 19
Page: 49-54
PDF size: 248.58 Kb.

ABSTRACT

Introduction: spinocerebellar ataxias (ScAs) are neurodegenerative, progressive, disabling and fatal diseases, characterized by great clinical and molecular heterogeneity. Objective: to determine factors associated with motor deterioration in patients with ScAs. Material and methods: observational, analytical, transversal study in 23 patients diagnosed with ScAs, in the province of Villa Clara, Cuba, during September-2019 and March-2021. The Epidemiological Survey for subjects with Ataxia was applied. For clinical evaluation, the Scale for the Assessment and Rating of Ataxias (SARA) was used. Descriptive statistical analysis was performed for each study variable, in a frequency distribution. To compare means of a variable corresponding to two independent groups, the Student's t-test (t) was used and for the multivariate analysis, an ANOVA variance study (F) was performed. The data was processed in SPSS v.22 for Windows. Results: the mean SARA score ± standard deviation (SD) was 24.93 ± 14.25 in women; 22.50 ± 11.19 in men; 28.20 ± 15.27 in non-white patients and 22.94 ± 12.62 in whites. The ANOVA analysis indicated higher mean SARA ± SD score values for: patients with age of first manifestations at 10 years or less (32.50 ± 14.34), patients with ScA2 (35.00) and ScA3 (20.33 ± 15.31) and patients with more than 30 years of evolution. The mean SARA score values were significantly different between patients in different clinical stages (p = 0.000). Conclusion: ScAs represent a major health problem; several factors are associated with the progression of the disease, and imply a marked motor deterioration.

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