medigraphic.com
ISSN 1028-4818 (Electronic)

2022, Number 5

<< Back Next >>

Mul Med 2022; 26 (5)

Characterization of non-motor symptoms in patients with Parkinson's disease

Verdecia AM, Jacas CA, Milanés DJ, Frias VD, Odoardo AM

Language: Spanish
References: 21
Page:
PDF size: 189.06 Kb.


ABSTRACT

Introduction: Parkinson's disease is one of the most frequent degenerative diseases and is characterized by non-motor clinical manifestations.
Objective: to characterize the non-motor clinical manifestations of patients suffering from Parkinson's disease.
Methods: an observational, descriptive, cross-sectional study was conducted. The universe consisted of patients with Parkinson's disease who attended the movement disorders consultation of the Carlos Manuel de Céspedes General Provincial Hospital in the period from July 1, 2020 to December 31, 2020, while the sample was made up of patients who completed all clinimetric tests and who gave their informed consent to participate in the study.
Results: the mean age was 69.05 years, predominantly male. The average scores of the Montreal Cognitive Assessment and the Unified Parkinson's Disease Scale modified by the Society for Movement Disorders (part I) were 17.95 and 9.85 respectively.
Conclusions: The most affected domains were: urinary, gastrointestinal and sleep/fatigue. The average score obtained when applying the Montreal Cognitive Assessment was low. The non-motor impact of Parkinson's disease on daily life experiences was high.


REFERENCES

  1. Savica R, Grossardt BR, Rocca WA, Bower JH. Parkinson disease with and without Dementia: A prevalence study and future projections. Mov Disord 2018; 33(4): 537- 43.

  2. Tysnes OB, Storstein A. Epidemiology of Parkinson's disease. J Neural Transm (Vienna) 2017; 124(8): 901-5.

  3. Park JH, Kim DH, Kwon DY, Choi M, Kim S, Jung JH, et al. Trends in the incidence and prevalence of Parkinson's disease in Korea: a nationwide, population-based study. BMC Geriatr. [Internet]. 2019 [citado 18/10/2022]; 320. Disponible en: file:///C:/Users/Lucy/Downloads/s12877-019-1332-7.pdf3. .

  4. Yu RL, Wu RM, Chan AY, Mok V, Wu YR, Tilley BC, et al. Cross-Cultural Differences of the Non-Motor Symptoms Studied by the Traditional Chinese Version of the International Parkinson and Movement Disorder Society- Unified Parkinson's Disease Rating Scale. Mov Disord Clin Pract 2016; 4(1): 68-77.

  5. Salari M, Chitsaz A, Etemadifar M, Najafi MR, Mirmosayyeb O, Bemanalizadeh M, et al. Evaluation of non-motor symptoms and their impact on quality of life in patients with Parkinson's disease, Isfahan, Iran. Iran J Neurol. 2017; 16(3): 118-24.

  6. Valent F, Devigili G, Rinaldo S, Del Zotto S, Tullio A, Eleopra R. The epidemiology of Parkinson's disease in the Italian region Friuli Venezia Giulia: a population-based study with administrative data. Neurol Sci. 2018; 39(4): 699-704.

  7. Rodríguez Violante M, Velásquez Pérez L, Cervantes Arriaga A. Incidence rates of Parkinson's disease in Mexico: Analysis of 2014-2017 statistics. Rev Mex Neurocienc 2019; 20(3): 136-40.

  8. Giroud JL, Esteban EM, Collado Mesa F. Prevalencia de la enfermedad de Parkinson en un área urbana de la provincia Ciudad de La Habana, Cuba. Estudio poblacional. Neurol Publ Soc Esp Neurol 2000; 15(7): 269-73.

  9. Argüelles JL, Borroto Bermudez LA, Sosa Aguila LM, Rodriguez Carbajal A. Prevalence of Parkinson's disease in an urban area of Cienfuegos city. Int J Fam Commun Med 2019; 3(1): 12- 4.

  10. Kelly MJ, Lawton MA, Baig F, Ruffmann C, Barber TR, Lo C, et al. Predictors of motor complications in early Parkinson's disease: A prospective cohort study. Mov Disord 2019; 34(8): 1174- 83.

  11. Sánchez Martínez CM, Choreño Parra JA, Placencia Álvarez N, Nuñez Orozco L, Guadarrama Ortiz P. Frequency and Dynamics of Non-motor Symptoms Presentation in Hispanic Patients With Parkinson Disease. Front Neurol 2019; 10: 1197-210.

  12. Georgiev D, Hamberg K, Hariz M, Forsgren L, Hariz GM. Gender differences in Parkinson's disease: A clinical perspective. Acta Neurol Scand 2017; 136(6): 570-84.

  13. Merola A, Romagnolo A, Rosso M, Suri R, Berndt Z, Maule S, et al. Autonomic dysfunction in Parkinson's disease: A prospective cohort study. Mov Disord 2018; 33(3): 391- 7.

  14. Arguedas Vásquez K, Miranda Valverde E, Valerio Aguilar D, Hernández Gabarain H. Montreal Cognitive Assessment scale in patients with Parkinson Disease with normal scores in the Mini-Mental State Examination. Dement Neuropsychol. 2019; 13(1): 78-81.

  15. Chen YC, Huang YZ, Weng YH, Chen CC, Hung J, Lin YY, et al. Nonmotor symptoms of 820 Taiwanese patients with Parkinson's disease: an exploratory-comparative study. J Neurol. 2020; 267(5): 1499-507.

  16. Picillo M, Palladino R, Barone P, Erro R, Colosimo C, Marconi R, et al. The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson's disease. Eur J Neurol 2017; 24(6): 788-95.

  17. Vurture G, Peyronnet B, Palma JA, Sussman RD, Malacarne DR, Feigin A, et al. Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease. Int Neurourol J 2019; 23(3): 211-8.

  18. Wang J, Cao R, Huang T, Liu C, Fan Y. Urinary Dysfunction Is Associated with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson's Disease. Parkinsons Dis. 2020; 2020: 4981647.

  19. Jones JD, Rahmani E, Garcia E, Jacobs JP. Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease. Parkinsonism Relat Disord 2020; 72: 7-12.

  20. Lawton M, Baig F, Toulson G, Morovat A, Evetts SG, Ben-Shlomo Y, et al. Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort. Mov Disord 2020; 35(2): 279-87.

  21. Lawton M, Ben Shlomo Y, May MT, Baig F, Barber TR, Klein JC, et al. Developing and validating Parkinson's disease subtypes and their motor and cognitive progression. J Neurol Neurosurg Psychiatry 2018; 89(12): 1279-87.




2020     |     www.medigraphic.com