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2025, Number 6

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salud publica mex 2025; 67 (6)

Hypoxemia in Mexican adults as a function of altitude of residence above sea level, Ensanut 2024

Sánchez-Pájaro A, Guinto-Ramírez S, Mendoza-Alvarado LR, Pérez-Padilla R
Full text How to cite this article

Language: Spanish
References: 30
Page: 805-813
PDF size: 366.35 Kb.


Key words:

long term oxygen therapy, hypoxemia, altitude, aging, obesity, surveys Mexico.

ABSTRACT

Objective. To estimate the prevalence of chronic hypoxemia with requirements of domiciliary oxygen (SpO2 ≤88%), the prescription and use of domiciliary oxygen, as well as its predictors, in adults living in communities ›1 000 m above sea level in Mexico. Materials and methods. The study was part of the Encuesta Nacional de Salud y Nutrición 2024, a household-based, multistage, stratified, probability sampling survey with representativeness for the country and for urban and rural areas. Questions about home oxygen use were included, as well as the average of six measurements of SpO2 and pulse rate done at rest, seated, and breathing room air. Results. The prevalence of hypoxemia was 1.1% and increased with age, obesity, and altitude above sea level. This contrasts with the 3.4% of the population who reported an oxygen prescription, although only 19% had actually filled it. Of those receiving oxygen at home, 74% had no evidence of resting hypoxemia and used it for an average of 7.7 hours per day. Conclusions. One percent of adult Mexicans have hypoxemia at rest. Supplemental oxygen is prescribed without verification of hypoxemia or follow-up to confirm its persistence, and once prescribed, it is used by only one-fifth of patients for an insufficient amount of time. The use of home oxygen in Mexico does not adhere to international guidelines.


REFERENCES

  1. Graham HR, Jahan E, Subhi R, Azrin F, Maher JR, Miller JL, et al. Theprevalence of hypoxaemia in paediatric and adult patients in health-carefacilities in low-income and middle-income countries: a systematic reviewand meta-analysis. Lancet Glob Health. 2025;13(2):e222-e231. https://doi.org/10.1016/S2214-109X(24)00469-8

  2. Perez-Padilla R, Torre-Bouscoulet L, Muino A, Marquez MN, Lopez MV,de Oca MM, et al. Prevalence of oxygen desaturation and use of oxygenat home in adults at sea level and at moderate altitude. Eur Respir J.2006;27(3):594-9. https://doi.org/10.1183/09031936.06.00075005

  3. Kacmarek RM, Stoller JK, Heuer AJ. Egan’s Fundamentals of RespiratoryCare. Elsevier Health Sciences, 2019.

  4. Sarkar M, Niranjan N, Banyal P. Mechanisms of hypoxemia. Lung India.2017;34(1):47. https://doi.org/10.4103/0970-2113.197116

  5. Gaston AF, Durand F, Roca E, Doucende G, Hapkova I, Subirats E.Exercise-induced hypoxaemia developed at sea-level influences responsesto exercise at moderate altitude. PLoS ONE. 2016;11(9):e0161819.https://doi.org/10.1371/journal.pone.0161819

  6. Pérez-Padilla R. Population distribution residing at different altitudes.Arch Med Res. 2002;33(2):162-6. https://doi.org/10.1016/S0188-4409(01)00377-0

  7. Nocturnal Oxygen Therapy Trial G. Continuous or nocturnaloxygen therapy in hypoxemic chronic obstructive lung disease: aclinical trial. Nocturnal Oxygen Therapy Trial Group. Ann Intern Med.1980;93(3):391-8. https://doi.org/ 10.7326/0003-4819-93-3-391

  8. Jacobs SS, Krishnan JA, Lederer DJ, Ghazipura M, Hossain T, Tan AM, etal. Home oxygen therapy for adults with chronic lung disease. An officialAmerican Thoracic Society Clinical practice guideline. Am J Respir CritCare Med. 2020;202(10):e121-41. https://doi.org/10.1164/rccm.202009-3608ST

  9. Medical Research Council Working Party. Long term domiciliary oxygentherapy in chronic hypoxic cor pulmonale complicating chronic bronchitisand emphysema. Lancet. 1981;1(8222):681-6. https://doi.org/10.1016/S0140-6736(81)91970-X

  10. Torre-Bouscoulet L, Chávez-Plascencia E, Vázquez-García J, Perez-Padilla R. Precisión y exactitud de un oxímetro de pulso “de bolsillo” en laciudad de México. Rev Invest Clin. 2006;58(1):28-33.

  11. Lam F, Subhi R, Houdek J, Schroder K, Battu A, Graham H. Theprevalence of hypoxemia among pediatric and adult patients presentingto healthcare facilities in low- and middle-income countries: protocol fora systematic review and meta-analysis. Syst Rev. 2020;9(1):67. https://doi.org/10.1186/s13643-020-01326-5

  12. Romero-Martínez M, Shamah-Levy T, Barrientos-Gutiérrez T, Cuevas-Nasu L, Bautista-Arredondo S, Colchero MA, et al. Metodología y análisisde la Encuesta Nacional de Salud y Nutrición 2020-2024. Salud PublicaMex. 2024;66(6):879-85. https://doi.org/10.21149/16455

  13. Leeb G, Auchus I, Law T, Bickler P, Feiner J, Hashi S, et al. The performanceof 11 fingertip pulse oximeters during hypoxemia in healthyhuman participants with varied, quantified skin pigment. EBioMedicine.2024;102:105051. https://doi.org/10.1016/j.ebiom.2024.105051

  14. Beall CM, Almasy LA, Blangero J, Williams-Blangero S, BrittenhamGM, Strohl KP, et al. Percent of oxygen saturation of arterialhemoglobin among Bolivian Aymara at 3,900-4,000 m. Am J PhysAnthropol. 1999;108(1):41-51. https://doi.org/10.1002/(SICI)1096-8644(199901)108:1<41::AID-AJPA2>3.0.CO;2-K

  15. Crocker ME, Hossen S, Goodman D, Simkovich SM, Kirby M,Thompson LM, et al. Effects of high altitude on respiratory rate andoxygen saturation reference values in healthy infants and children youngerthan 2 years in four countries: a cross-sectional study. Lancet Glob Health.2020;8(3):e362-73. https://doi.org/10.1016/S2214-109X(19)30543-1

  16. Forrer A, Gaisl T, Sevik A, Meyer M, Senteler L, Lichtblau M, et al. Partialpressure of arterial oxygen in healthy adults at high altitudes: a systematicreview and meta-analysis. JAMA Netw Open. 2023;6(6):e2318036. https://doi.org/10.1001/jamanetworkopen.2023.18036

  17. Mallat J, Rahman N, Hamed F, Hernandez G, Fischer M-O. Pathophysiology,mechanisms, and managements of tissue hypoxia. Anaesth Crit Care PainMed. 20222;41(4):101087. https://doi.org/10.1016/j.accpm.2022.101087

  18. Rojas-Camayo J, Mejia CR, Callacondo D, Dawson JA, Posso M, GalvanCA, et al. Reference values for oxygen saturation from sea level to thehighest human habitation in the Andes in acclimatised persons. Thorax.2018;73(8):776-8. https://doi.org/10.1136/thoraxjnl-2017-210598

  19. Shapiro I, Stein J, MacRae C, O’Reilly M. Pulse oximetry values from33,080 participants in the Apple Heart & Movement Study. NPJ Digit Med.

  20. 2023;6(1):134. https://doi.org/10.1038/s41746-023-00851-620. Soria R, Egger M, Scherrer U, Bender N, Rimoldi SF. Pulmonaryartery pressure and arterial oxygen saturation in people living at highor low altitude: systematic review and meta-analysis. J Appl Physiol.2016;121(5):1151-9. https://doi.org/10.1152/japplphysiol.00394.2016

  21. Ucros S, Granados CM, Castro-Rodriguez JA, Hill CM. Oxygen saturationin childhood at high altitude: a systematic review. High Alt Med Biol.2020;21(2):114-25. https://doi.org/10.1089/ham.2019.0077

  22. Zysman M, Deslee G, Perez T, Burgel PR, Le Rouzic O, Brinchault-RabinG, et al. Burden and characteristics of severe chronic hypoxemia in a realworldcohort of subjects with COPD. Int J Chron Obstruct Pulmon Dis.2021;16:1275-84. https://doi.org/10.2147/COPD.S295381

  23. Chowdhury MZI, Turin TC. Variable selection strategies and itsimportance in clinical prediction modelling. Fam Med Community Health.2020;8(1):e000262. https://doi.org/10.1136/fmch-2019-000262

  24. Sánchez-Pájaro A, Guinto-Ramírez S, Mendoza-Alvarado LR, Pérez-Padilla R. Material suplementario. Figshare, 2025. https://doi.org/10.6084/m9.figshare.30214897

  25. Anderson MR, Shashaty MGS. Impact of obesity in critical illness. Chest.2021;160(6):2135-45. https://doi.org/10.1016/j.chest.2021.08.001

  26. Barrera-Núñez DA, López-Olmedo N, Zavala-Arciniega L, Barrientos-Gutiérrez I, Reynales-Shigematsu LM. Consumo de tabaco y uso de cigarroelectrónico en adolescentes y adultos mexicanos. Ensanut Continua 2022.Salud Publica Mex. 2023;65:s65-s74 [citado noviembre 11, 2025]. Disponibleen: https://www.saludpublica.mx/index.php/spm/article/view/14830

  27. Engin A. Adipose tissue hypoxia in obesity: clinical reappraisal ofhypoxia hypothesis. In: Engin AB, Engin A, eds. Obesity and Lipotoxicity.Springer Internatsional Publishing, 2024:329-356. https://doi.org/10.1007/978-3-031-63657-8_11

  28. Ekström M, Andersson A, Papadopoulos S, Kipper T, Pedersen B, KrickaO, et al. Long-term oxygen therapy for 24 or 15 hours per day in severehypoxemia. N Engl J Med. 2024;391(11):977-88. https://doi.org/10.1056/NEJMoa2402638

  29. Hungin AP, Chinn DJ, Convery B, Dean C, Cornford CS, Russell A. Theprescribing and follow-up of domiciliary oxygen--whose responsibility? Asurvey of prescribing from primary care. Br J Gen Pract. 2003;53(494):714-5.

  30. Andersson A, Strom K, Brodin H, Alton M, Boman G, Jakobsson P, et al.Domiciliary liquid oxygen versus concentrator treatment in chronic hypoxaemia: a cost-utility analysis. Eur Respir J. 1998;12(6):1284-9. https://doi.org/10.1183/09031936.98.12061284




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salud publica mex. 2025;67