medigraphic.com

2022, Number 3

Next >>

Rev Cuba Endoc 2022; 33 (3)

Factors associated with the risk of developing ischemic heart disease in people with diabetes mellitus

Valdés RER, Álvarez AA

Language: Spanish
References: 28
Page:
PDF size: 647.34 Kb.


ABSTRACT

Introduction: Ischemic heart disease is the most relevant clinical problem of atherosclerosis in individuals with diabetes mellitus.
Objective: To identify the factors associated with the risk of developing ischemic heart disease in people with diabetes mellitus.
Methods: A case-control analytical study was conducted in 459 patients with diabetes mellitus attended at the endocrinology and cardiology services of “Carlos Manuel de Céspedes” Hospital in Granma province, in the period from January 1st, 2015 to December 31, 2020. Classic and non-classical cardiovascular risk factors were evaluated, as well as some conditions typical of diabetes. Data were processed with student's t and chi-squared.
Results: The multivariate analysis showed that nine factors increased the risk of presenting ischemic heart disease independently, where stand out: peripheral arterial disease (OR = 11.51; CI = 4.8-27.4; p = 0.000); hypertension (OR = 7.66; CI = 2.9-19.6; p = 0.000); left ventricular hypertrophy (OR = 4.96; CI = 2.3-10.6; p = 0.000); microalbuminuria (OR = 3.66; CI = 1.9-6.9; p = 0.000) and decreased high-density lipoprotein cholesterol (OR = 3.57; CI = 1.7-7.4; p = 0.001). The Hosmer and Lemeshow test showed that the data fit the model (p = 0.510).
Conclusions: A model was obtained that demonstrated the independent value of nine risk factors for ischemic heart disease in people with diabetes mellitus. Peripheral arterial disease, arterial hypertension, left ventricular hypertrophy, microalbuminuria and decreased cholesterol bound to high-density lipoproteins stand out.


REFERENCES

  1. Grupo de Trabajo de la Sociedad Europea de Cardiología (ESC) sobre el diagnóstico y el tratamiento de los síndromes coronarios crónicos. Guía ESC 2019 sobre el diagnóstico y tratamiento de los síndromes coronarios crónicos. Rev Esp Cardiol. 2020 [acceso 15/02/2022];73(6):495.e1-e61. Disponible en: https://www.revespcardiol.org/es-pdf-S0300893220301007

  2. Glovaci D, Fan W, Wong ND. Epidemiology of Diabetes Mellitus and Cardiovascular Disease. Curr Cardiol Rep. 2019 [acceso 15/02/2022];21(4):21. Disponible en: https://link.springer.com/article/10.1007/s11886-019-1107-y

  3. Arrieta F, Iglesias P, Botet JP, Becerra A, Ortega E, Obaya JC, et al. Diabetes mellitus y riesgo cardiovascular. Actualización de las recomendaciones del Grupo de Trabajo de Diabetes y Riesgo Cardiovascular de la Sociedad Española de Diabetes (SED, 2018). Clínica e Investigación en Arteriosclerosis. 2018 [acceso 15/02/2022];30(3):137-53. Disponible en: https://www.elsevier.es/es-revista-clinica-e-investigacion-arteriosclerosis-15-articulo-diabetes-mellitus-riesgo-cardiovascular-actualizacion-S0214916818300330

  4. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019 [acceso 15/02/2022];62(1):3-16. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30171279/

  5. Thygesen K, Alpert J, Jaffe A, Chaitman B, Bax J, Morrow DA, et al. Consenso ESC 2018 sobre la cuarta definición universal del infarto de miocardio. Rev Esp Cardiol. 2019 [acceso 15/02/2022]; 72(1):72.e1-e27. Disponible en: https://www.revespcardiol.org/es-pdf-S0300893218306365

  6. American Diabetes Association. Clasificación y diagnóstico de la diabetes: Estándares para la Atención Médica de la Diabetes_2019. Diabetes Care. 2019 [acceso 15/02/2022];42(Suppl.1):S13-S28. Disponible en: https://diabetesjournals.org/care/article/42/Supplement_1/S13/31150/2-Classification-and-Diagnosis-of-Diabetes

  7. Carrera Y. Cuestionario Internacional de actividad física. Revista Enfermería del Trabajo. 2017 acceso 15/02/2022];2(7):49-54. Disponible en: https://www.enfermeria21.com/revistas/trabajo/articulo/39/cuestionario-internacional-de-actividad-fisica-ipaq/

  8. Pérez MD, León JL, Dueñas A, Alfonzo JP, Navarro DA, de la Noval R, et al. Guía cubana de diagnóstico, evaluación y tratamiento de la hipertensión arterial. Rev cubana med. 2017 [acceso 15/02/2022];56(4):242-321. Disponible en: http://scielo.sld.cu/pdf/med/v56n4/med01417.pdf

  9. Comité de expertos de la OMS. El estado físico: uso e interpretación de la antropometría. OMS. 1995 [acceso 15/02/2022]. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/42132/WHO_TRS_854_spa.pdf?sequence=1&isAllowed=y

  10. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of The Third Report of The National Cholesterol Education Program (NCEP), Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001 [acceso 15/02/2022];285(19):2486-97. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11368702/

  11. Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J. 1949 [acceso 15/02/2022];37(2):161-86. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/0002870349905621?via%3Dihub

  12. Casale PN, Devereux RB, Alonso DR, Campo E, Kligfield P. Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: validation with autopsy findings. Circulation. 1987 [acceso 15/02/2022];75(3):565-72. Disponible en: https://pubmed.ncbi.nlm.nih.gov/2949887/

  13. World Medical Association Declaration of Helsinki: Ethical principles for medical Research Involving Human Subjects. JAMA. 2013;310(20):1-95. DOI: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2013.281053

  14. Valdés- Ramos ER, Valdés Bencosme ER, Valdés Bencosme N. Factores de riesgo asociados a las complicaciones cardiovasculares en mujeres de edad mediana con diabetes mellitus tipo 2. Rev Cuban Endocrinol. 2020 [acceso 15/02/2022];31(2):e229. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532020000200006

  15. Valdés-Ramos E, Bencosme-Rodríguez N, Morales-Villavicencio B. Frecuencia y factores relacionados con la aparición de cardiopatía isquémica en diabéticos tipo 2. MULTIMED. 2017 [acceso 10/01/2022];19(3). Disponible en: http://www.revmultimed.sld.cu/index.php/mtm/article/view/352.

  16. Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment on outcome incidence in hypertension: 10 – Should blood pressure management differ in hypertensive patients with and without diabetes mellitus? Overview and meta-analyses of randomized trials. J Hypertens 2017 [acceso 15/02/2022];35(5):922-44. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28141660/

  17. Śliwińska-Mossoń M, Milnerowicz H. The impact of smoking on the development of diabetes and its complications. Diab Vasc Dis Res. 2017 [acceso 15/02/2022];14(4):265-76. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28393534/

  18. López Zubizarreta M, Hernández Mezquita M Á, Miralles García J M, Barrueco Ferrero M. Tabaco y diabetes: relevancia clínica y abordaje de la deshabituación tabáquica en pacientes con diabetes. Endocrinología, Diabetes y Nutrición. (2017);64(4):221-31. DOI: https://doi.org/10.1016/j.endien.2017.05.003

  19. Chait A, Goldberg I. Treatment of dyslipidemia in diabetes: recent advances and remaining questions. Curr Diab Rep. 2017;17:112. DOI: https://doi.org/10.1007/s11892-017-0942-8

  20. Cardner M, Yalcinkaya M, Goetze S, Luca E, Balaz M, Hunjadi M, et al. Structure-function relationships of HDL in diabetes and coronary heart disease. JCI Insight. 2020 [acceso 15/02/2022];5(1):131491. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030825/

  21. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, et al. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353(25):2643-53. DOI: https://doi.org/10.1056/NEJMoa052187.

  22. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89. DOI: https://doi.org/10.1056/NEJMoa0806470.

  23. American Diabetes Association. 6. Glycemic targets: Standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Supl 1):S55-S64. DOI: https://doi.org/10.2337/dc18-S006.

  24. Gimeno Orna JA, Blasco Lamarca Y, Campos Gutiérrez B, Molinero Herguedas E, Lou Arnal LM. Riesgo de morbimortalidad cardiovascular según el tiempo de evolución de la diabetes tipo 2. Clin Invest Arterioscl. 2014 [acceso 15/02/2022];26(3):122-30. Disponible en: https://www.elsevier.es/es-revista-clinica-e-investigacion-arteriosclerosis-15-articulo-riesgo-morbimortalidad-cardiovascular-segun-el-S0214916813001344?code=4ey9xNIn2rRB0hqg5ia8FEjfXHS3At&newsletter=true

  25. Valdés-Ramos E, Camps Arjona MC, Verdecia Saborit R. Factores de riesgo y enfermedad cardiovascular en diabéticos tipo 2 de diagnóstico reciente. Rev Cubana Invest Bioméd. 2014 [acceso 17/05/2016];33(2):177-85. Disponible en: http://scielo.sld.cu/ scielo.php?script=sci_arttext&pid=S0864-03002014000200009&lng=es.

  26. Minutolo R, Gabbai FB, Provenzano M, Chiodini P, Borrelli S, Garofalo C, et al. Cardiorenal prognosis by residual proteinuria level in diabetic chronic kidney disease: pooled analysis of four cohort studies. Nephrol Dial Transplant. 2018 [acceso 15/02/2022];33(11):1942-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29509925/

  27. Félix-Redondo FJ, Subirana I, Baena-Diez JM, Ramos R, Cancho B, Fernández Bergés D, et al. Importancia pronóstica de la enfermedad arterial periférica diagnosticada mediante el índice tobillo-brazo en población general española. Aten Primaria. 2020 [acceso 15/02/2022];52(9):627-36. Disponible en: https://www.sciencedirect.com/science/article/pii/S0212656720301062

  28. Kawel-Boehm N, Kronmal R, Eng J, Folsom A, Burke G, Carr JJ, et al. Left Ventricular Mass at MRI and Long-Term Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis (MESA). Radiology. 2019 [acceso 15/02/2022];293(1):107-14. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776886/




2020     |     www.medigraphic.com