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2026, Number 2

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Rev Mex Anest 2026; 49 (2)

Perioperative management of Glanzmann's thrombasthenia and pregnancy. A case report

Cano-Gálvez MA, Zebadua-Jiménez VH, Ortíz-Ibarra FJ
Full text How to cite this article 10.35366/122911

DOI

DOI: 10.35366/122911
URL: https://dx.doi.org/10.35366/122911

Language: Spanish
References: 19
Page: 126-129
PDF size: 415.30 Kb.


Key words:

Glanzmann´s thrombasthenia, pregnancy, regional anesthesia.

ABSTRACT

A 32-year-old patient with a diagnosis of Glanzmann's thrombasthenia, with a full-term pregnancy with multidisciplinary control with hematology and obstetrics, the pregnancy was terminated on a scheduled basis. Regional anesthesia was decided to avoid the risks of airway instrumentation in the pregnant patient. Platelet apheresis was administered prior to the start of the anesthetic procedure, a viable product was obtained, with final bleeding slightly greater than usual, so the administration of alternative therapies such as factor VII or antifibrinolytics was not necessary. There were no subsequent bleeding events, hospital discharge at 72 hours with no complications related to the underlying pathology.


REFERENCES

  1. Reyes-Hernández MU, Sandoval García-Travesí FA, Morales-Hernández S, Villalpando-Rosales M, Sandoval-Barajas D, Reyes-Gómez U. Trombastenia de Glanzmann y embarazo: reporte de un caso y revisión bibliográfica. Ginecol Obstet Mex. 2016;84:674-678.

  2. Duman EN, Saylan S, Cekic B. Conducta en el perioperatorio de paciente pediátrico con trombastenia de Glanzmann durante la adenoidectomía. Rev Bras Anestesiol. 2012;62:1-3.

  3. Wijemanne A, Watt-Coote I, Austin S. Glanzmann thrombasthenia in pregnancy: optimising maternal and fetal outcomes. Obstet Med. 2016;9:169-170.

  4. Kulkarni B, Ghosh K, Shetty S. Second trimester prenatal diagnosis in Glanzmann's thrombasthenia. Haemophilia. 2016;22:e99-e118.

  5. Kannan M, Saxena R. Glanzmann's thrombasthenia: an overview. Clin Appl Thromb Hemost. 2009;15:152-165.

  6. Varkey I, Rai K, Hegde AM, Vijaya MS, Oommen VI. Clinical management of Glanzmann's thrombasthenia: a case report. J Dent (Tehran). 2014;11:242-247.

  7. Siddiq S, Clark A, Mumford A. A systematic review of the management and outcomes of pregnancy in Glanzmann thrombasthenia. Haemophilia. 2011;17:e858-e869.

  8. Martínez Sánchez LM, Quintero Moreno DA. Trombastenia de Glanzmann: conceptos clave de la enfermedad. Rev Cubana Hematol Inmunol Hemoter. 2019;35:1-12.

  9. Trujillo Mejía A, López Pérez C. Perioperative considerations in a girl with Glanzmann thrombasthenia. Case report. Rev Colomb Anestesiol. 2021;49:e600.

  10. Binder A, Aledort L. Glanzmann's thrombasthenia: meeting the anticoagulation challenge. Haemophilia. 2015;21:e322-e343.

  11. Yilmaz E, Turhan U, Simsek Y, Celik O, Karaer A, Minareci Y. Management of term pregnancy diagnosed with Glanzmann thrombasthenia: a case report. Perinatal Journal. 2011;19:137-139.

  12. Kumar N, Khan AA, Kumar N, Bindra A, Mahajan C, Goyal K. Glanzmann thrombasthenia and its perioperative management in head trauma: a rare and challenging situation. J Neuroanaesthesiol Crit Care. 2016;3:52-55.

  13. Duman EN, Saylan S, Cekic B. Perioperative management of a pediatric patient with Glanzmann's thrombasthenia during adenoidectomy. Rev Bras Anestesiol. 2012;62:548-553.

  14. Saultier P, Grino M, Falaise C, Voisin S, Lavenu-Bombled C, Ibrahim-Kosta M, et al. Efficacy and safety of recombinant activated factor VII in Glanzmann thrombasthenia: A systematic literature review. Haemophilia. 2025;31:7-15.

  15. Bosilah AH, Eldesouky E, Alghazaly MM, Farag E, Sultan EEK, Alazazy H, et al. Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy. BMC Pregnancy Childbirth. 2023;23:433.

  16. Fusca L, Perelman I, Fergusson D, Boutet M, Chen I. The effectiveness of tranexamic acid at reducing blood loss and transfusion requirement for women undergoing myomectomy: a systematic review and meta-analysis. J Obstet Gynaecol Can. 2019;41:1185-1192.e1.

  17. Cabarique-Serrano SH, González-Cárdenas VH, Dussán-Crosby JP, Páez-González RE, Ramírez MA. Anestesia epidural para artrodesis e instrumentación de columna lumbar por vía posterior en paciente con trombastenia de Glanzmann: informe de caso y revisión sistemática. Rev Colomb Anestesiol. 2016;44:250-255.

  18. Bell JA, Savidge GF. Glanzmann's thrombasthenia proposed optimal management during surgery and delivery. Clin Appl Thromb Hemost. 2003;9:167-170.

  19. Monte S, Lyons G. Peripartum management of a patient with Glanzmann's thrombasthenia using thrombelastograph. Br J Anaesth. 2001;87:734-738.




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Rev Mex Anest. 2026;49