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2026, Number 1

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Med Crit 2026; 40 (1)

Increased plasminogen activator inhibitor 1 (PAI-1) like immunomodulator in a patient with extended spectrum beta-lactamase Klebsiella isolate

Giraldo SJM, Barranco J
Full text How to cite this article 10.35366/123044

DOI

DOI: 10.35366/123044
URL: https://dx.doi.org/10.35366/123044

Language: Spanish
References: 21
Page: 75-79
PDF size: 579.16 Kb.


Key words:

sepsis, hypoperfusion, plasminogen, fibrinolysis, neutrophil.

ABSTRACT

Hematological injury within the spectrum of organ dysfunctions during the systemic inflammatory response to the circulating inoculum has a great variety in its clinical presentation; it can range from disseminated intravascular coagulation to dysregulation in fibrinolysis through modifications in the plasminogenesis activation. We present the clinical case of a patient in her fifth decade of life who had elevated serum levels of plasminogen activator inhibitor-1 (PAI-1), causing interesting phenomena that could be directly related to the clinical outcome.


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Med Crit. 2026;40