Giraldo SJM, Barranco J

Language: Spanish
References: 21
Page: 75-79
PDF size: 579.16 Kb.

ABSTRACT

Hematological injury within the spectrum of organ dysfunctions during the systemic inflammatory response to the circulating inoculum has a great variety in its clinical presentation; it can range from disseminated intravascular coagulation to dysregulation in fibrinolysis through modifications in the plasminogenesis activation. We present the clinical case of a patient in her fifth decade of life who had elevated serum levels of plasminogen activator inhibitor-1 (PAI-1), causing interesting phenomena that could be directly related to the clinical outcome.

REFERENCES

1. Konstantinides S, Schafer K, Thinnes T, Loskutoff DJ. Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice. Circulation. 2001;103(4):576-583. doi: 10.1161/01.cir.103.4.576.

2. Stringer HA, van Swieten P, Heijnen HF, Sixma JJ, Pannekoek H. Plasminogen activator inhibitor-1 released from activated platelets plays a key role in thrombolysis resistance. Studies with thrombi generated in the Chandler loop. Arterioscler Thromb. 1994;14(9):1452-1458. doi: 10.1161/01.atv.14.9.1452.

3. Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC. Airway management. In: Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC, editors. Clinical anesthesia. 6th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2009. p. 751-777.

4. Finucane BT, Tsui BCH, Santora AH. Chapter 9. The difficult airway. In: Principles of airway management. 4th ed. New York: Springer; 2011. pp. 361-414.

5. Vincent JL, Bakker J. Blood lactate levels in sepsis: in 8 questions. Curr Opin Crit Care. 2021;27(3):298-302.

6. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):762-774.

7. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580-637.

8. Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, et al. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med. 2016;42(10):1567-1575.

9. Hassan A, Usman J, Kaleem F, Gill MM, Khalid A, Iqbal M, et al. Evaluation of different phenotypic methods for detection of amp C Beta-lactamase producing bacteria in clinical isolates. J Coll Physicians Surg Pak. 2013;23(9):629-632.

10. Aliberti S, Di Pasquale M, Zanaboni AM, Cosentini R, Brambilla AM, Seghezzi S, et al. Stratifying risk factors for multidrug-resistant pathogens in hospitalized patients coming from the community with pneumonia. Clin Infect Dis. 2012;54(4):470-478.

11. Giraldo J, Badillo E, Pacheco J, Beltrán E, Barranco E. Liberación de la ventilación mecánica con sistema de asa cerrada en asistencia proporcional en paciente con síndrome de dificultad respiratoria del adulto de origen extrapulmonar. Acta Colomb Cuid Intens. 2015;15:132-142.

12. Giraldo J, Beltrán E, Barranco E, Badillo E, Pacheco J. Liberación de la ventilación mecánica direccionada por sistemas de asa cerrada en asistencia proporcional (PAV) en paciente con síndrome de dificultad respiratoria del adulto secundario a tuberculosis pulmonar y sida. Acta Colomb Cuid Intens. 2017;17:139-144.

13. Esteban A, Frutos F, Tobin MJ, Alía I, Solsona JF, Valverdú I, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med. 1995;332(6):345-350.

14. Rello J, Rodríguez A, Lisboa T, Gallego M, Luján M, Wunderink R. Puntuación PIRO para neumonía adquirida en la comunidad: una nueva regla de predicción para la evaluación de la gravedad en pacientes de la unidad de cuidados intensivos con neumonía adquirida en la comunidad. Crit Care Med. 2009;37:456-462.

15. Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38-44.

16. Renckens R, Roelofs JJ, Bonta PI, Florquin S, de Vries CJ, Levi M, et al. Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. Blood. 2007;109(4):1593-1601.

17. Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, et al. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J Immunol. 2011;186(2):1119-1130.

18. Giuffré M, Verso CL, Serra G, Moceri G, Cimador M, Corsello G; Study Group of Neonatal Infectious Diseases Affiliated to the Italian Society of Neonatology. Portal vein thrombosis in a preterm newborn with mutation of the MTHFR and PAI-1 genes and sepsis by Candida parapsilosis. Am J Perinatol. 2016;33(11):1099-1103.

19. Duburcq T, Tournoys A, Gnemmi V, Hubert T, Gmyr V, Pattou F, et al. Impact of obesity on endotoxin-induced disseminated intravascular coagulation. Shock. 2015;44(4):341-347.

20. Gao WF, Guo YB, Bai Y, Ding XY, Yan YJ, Wu ZQ. Association between PAI-1 4G/5G polymorphism and diabetic nephropathy: a meta-analysis in the Chinese population. Int Urol Nephrol. 2016;48(9):1483-1489.

21. Palmer OMP, Carter M, Chang CH, Lucko N, Jackson VM, Sun Q, et al. Effects of transport temperature on the stability of inflammatory, hemostasis, endothelial function, and oxidative stress plasma biomarker concentrations. Shock. 2017;47(6):715-719.