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2025, Number 1

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Rev Cent Dermatol Pascua 2025; 34 (1)

Molecular and immunological mechanisms of ultraviolet light in dermatology

Domínguez-Gómez MA, Carrillo-Guajardo AY

Language: Spanish
References: 11
Page: 5-10
PDF size: 648.77 Kb.


ABSTRACT

Ultraviolet (UV) radiation is a key environmental factor in cutaneous pathophysiology, with dual effects ranging from vitamin D synthesis to immunosuppression and carcinogenesis. UVB causes direct DNA damage, while UVA generates oxidative stress, triggering inflammatory and immunomodulatory responses. Clinically, these mechanisms manifest as erythema, pigmentation, photoaging, and the development of cutaneous neoplasms. Additionally, visible light, particularly in individuals with darker phototypes, contributes to persistent hyperpigmentation. Sun exposure also influences mental health through neuroendocrine pathways, highlighting the role of the skin-brain axis. Understanding these processes is essential for the safe and effective use of phototherapy, as well as for designing comprehensive photoprotection strategies.


REFERENCES

  1. Grzybowski A, Sak J, Pawlikowski J. A brief report on the historyof phototherapy. Clin Dermatol. 2016; 34: 532-537. doi: 10.1016/j.clindermatol.2016.05.002.

  2. Enwemeka CS, Baker TL, Bumah VV. The role of UV and blue light inphoto-eradication of microorganisms. J Photochem Photobiol. 2021;8: 100064. doi: 10.1016/j.jpap.2021.100064.

  3. Grzybowski A, Pietrzak K. From patient to discoverer--NielsRyberg Finsen (1860–1904) --the founder of phototherapy indermatology. Clin Dermatol. 2012; 30: 451-455. doi: 10.1016/j.clindermatol.2011.11.019.

  4. Bernard JJ, Gallo RL, Krutmann J. Photoimmunology: how ultravioletradiation affects the immune system. Nat Rev Immunol. 2019; 19:688-701. doi: 10.1038/s41577-019-0185-9.

  5. Yu ZW, Zheng M, Fan HY, Liang XH, Tang YL. Ultraviolet (UV)radiation: a double-edged sword in cancer development andtherapy. Mol Biomed. 2024; 5:49. doi: 10.1186/s43556-024-00209-8.

  6. Ghajar-Rahimi G, Yusuf N, Xu H. Ultraviolet radiation-inducedtolerogenic dendritic cells in skin: insights and mechanisms. Cells.2025; 14: 308. doi: 10.3390/cells14040308.

  7. Ansari U, Harvey VM. Other effects of ultraviolet light: photosensitivity,photoreactivity, and photoaging. In: Li BS, Maibach HI, editors. Ethnicskin and hair and other cultural considerations. Updates in ClinicalDermatology. Cham: Springer; 2021. pp. 55-70. Available in: https://doi.org/10.1007/978-3-030-64830-5_6

  8. Bernerd F, Passeron T, Castiel I, Marionnet C. The damagingeffects of long UVA (UVA1) rays: a major challenge to preserveskin health and integrity. Int J Mol Sci. 2022; 23: 8243. doi: 10.3390/ijms23158243.

  9. Brar G, Dhaliwal A, Brar AS, Sreedevi M, Ahmadi Y, Irfan M et al.A comprehensive review of the role of UV radiation in photoagingprocesses between different types of skin. Cureus. 2025; 17: e81109.doi: 10.7759/cureus.81109.

  10. Tang X, Yang T, Yu D, Xiong H, Zhang S. Current insights and futureperspectives of ultraviolet radiation (UV) exposure: Friends and foesto the skin and beyond the skin. Environ Int. 2024; 185: 108535. doi:10.1016/j.envint.2024.108535.

  11. Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. HowUV light touches the brain and endocrine system through skin, and why.Endocrinology. 2018; 159: 1992-2007. doi: 10.1210/en.2017-03230.




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