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2025, Number 1

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Rev Cent Dermatol Pascua 2025; 34 (1)

Molecular and immunological mechanisms of ultraviolet light in dermatology

Domínguez-Gómez MA, Carrillo-Guajardo AY

Language: Spanish
References: 11
Page: 5-10
PDF size: 648.77 Kb.


ABSTRACT

Ultraviolet (UV) radiation is a key environmental factor in cutaneous pathophysiology, with dual effects ranging from vitamin D synthesis to immunosuppression and carcinogenesis. UVB causes direct DNA damage, while UVA generates oxidative stress, triggering inflammatory and immunomodulatory responses. Clinically, these mechanisms manifest as erythema, pigmentation, photoaging, and the development of cutaneous neoplasms. Additionally, visible light, particularly in individuals with darker phototypes, contributes to persistent hyperpigmentation. Sun exposure also influences mental health through neuroendocrine pathways, highlighting the role of the skin-brain axis. Understanding these processes is essential for the safe and effective use of phototherapy, as well as for designing comprehensive photoprotection strategies.


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