2022, Number 4
<< Back Next >>
Rev cubana med 2022; 61 (4)
Impact of hypertensive retinopathy associated with coronary heart disease
Olivas-Valencia DR, Vela-Ruiz JM, De La Cruz-Vargas JA
Language: Spanish
References: 42
Page: 1-16
PDF size: 539.74 Kb.
ABSTRACT
Introduction:
The association between hypertensive retinopathy and coronary heart disease is a subject of long-standing controversy. Hypertensive retinopathy has long been defined as a predictor of mortality and morbidity in hypertensive patients. In addition, recent studies have shown that the retinal microvasculature reflects pathology in small systemic vessels, including the coronary microcirculation.
Objectives:
The aim was to perform a systematic review and a qualitative and quantitative analysis by meta-analysis to determine the association between hypertensive retinopathy and coronary heart disease.
Methods:
A systematic search for studies related to the topic was performed. The search source was PubMed and Google Scholar. The systematic review and meta-analysis were developed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.
Results:
An association between hypertensive retinopathy and coronary artery disease was demonstrated (P=0.01; RR 1.29; 95 % CI: 1.06 to 1.56), left ventricular hypertrophy was evaluated as an outcome, a statistically significant effect was found associating hypertensive retinopathy with left ventricular hypertrophy (P=0.03; RR: 1.71; 95 % CI: 1.31 to 2.24).
Conclusions:
An association was found between hypertensive retinopathy and the most frequent coronary heart diseases (coronary artery disease and LVH).
REFERENCES
Lewington SCR, Qizilbash N, Peto R, Collins. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. The Lancet. 2002;360(9349):1903-13. DOI: https://doi.org/10.1016/S0140-6736(02)11911-81.
Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global Disparities of Hypertension Prevalence and Control: A Systematic Analysis of Population-Based Studies From 90 Countries. Circulation. 2016;134(6):441-50. DOI: https://doi.org/10.1161/CIRCULATIONAHA.115.018912
Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M, et al3. . Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. diciembre de 2015;386(10010):2287-323. DOI: https://doi.org/10.1001/jama.2016.190433.
Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, et al. British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ. 13 de marzo de 2004;328(7440):634-40. DOI: https://doi.org/10.1136/bmj.328.7440.634
Cheng L, Barlis P, Gibson J, Colville D, Hutchinson A, Gleeson G, et al. Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study. Malik RA, editor. PLoS ONE. 2018;13(5). DOI: https://doi.org/10.1371/journal.pone.01923505.
Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. Journal of the American College of Cardiology. 2017;70(1):1-25. DOI: https://doi.org/10.1016/j.jacc.2017.04.0526.
Mathers CD, Loncar D. Projections of Global Mortality and Burden of Disease from 2002 to 2030. Samet J, editor. PLoS Med. 2006;3(11):e442. DOI: https://doi.org/10.1371/journal.pmed.00304427.
Cannon RO. Microvascular Angina and the Continuing Dilemma of Chest Pain With Normal Coronary Angiograms. Journal of the American College of Cardiology. 2009;54(10):877-85. DOI: https://doi.org/10.1016/j.jacc.2009.03.0808.
Maseri A, Crea F, Kaski JC, Crake T. Mechanisms of angina pectoris in syndrome X. Journal of the American College of Cardiology. 1991;17(2):499-506. DOI: dhttps://oi.org/10.1016/S0735-1097(10)80122-69.
Wong TY. Quantitative Retinal Venular Caliber and Risk of Cardiovascular Disease in Older Persons: The Cardiovascular Health Study. Arch Intern Med. 2006;166(21):2388. DOI: https://doi.org/10.1001/archinte.166.21.238810.
Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Tielsch JM, et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA. 2002;287(9):1153-9. DOI: https://doi.org/10.1001/jama.287.9.115311.
Kim G-H, Youn H-J, Kang S, Choi Y-S, Moon J-I. Relation Between Grade II Hypertensive Retinopathy and Coronary Artery Disease in Treated Essential Hypertensives. Clinical and Experimental Hypertension. 2010;32(7):469-73. DOI: https://doi.org/10.3109/10641963.2010.49651512.
Wang L, Wong TY, Sharrett AR, Klein R, Folsom AR, Jerosch-Herold M. Relationship Between Retinal Arteriolar Narrowing and Myocardial Perfusion: Multi-Ethnic Study of Atherosclerosis. Hypertension. 2008;51(1):119-26. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.107.09834313.
Wang JJ, Liew G, Klein R, Rochtchina E, Knudtson MD, Klein BEK, et al. Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations. European Heart Journal. 2007;28(16):1984-92. DOI: https://doi.org/10.1093/eurheartj/ehm221
Wong TY, Klein R, Nieto FJ, Klein BEK, Sharrett AR, Meuer SM, et al. Retinal microvascular abnormalities and 10-year cardiovascular mortality. Ophthalmology. 2003;110(5):933-40. DOI: https://doi.org/10.1016/S0161-6420(03)00084-815.
Habib SA, Jibran MS, Khan SB, Gul AM. Association Of Hypertensive Retinopathy With Angiographic Severity Of Coronary Artery Disease Determined By Syntax Score. J Ayub Med Coll Abbottabad. 2019;31(2):189-91. Disponible en: PMID: 31094114
Shantha GPS, Srinivasan Y, Kumar AA, Salim S, Prabakhar S, Rajan AG, et al. Can retinal changes predict coronary artery disease in elderly hypertensive patients presenting with angina? The American Journal of Emergency Medicine. 2010;28(5):617-21.
Wong TY, Mitchell P. Hypertensive Retinopathy. N Engl J Med. 2004;351(22):2310-7. DOI: https://doi.org/10.1056/NEJMra03286518.
Wang SB, Mitchell P, Liew G, Wong TY, Phan K, Thiagalingam A, et al. A spectrum of retinal vasculature measures and coronary artery disease. Atherosclerosis. 2018;268:215-24. DOI: https://doi.org/10.1016/j.atherosclerosis.2017.10.00819.
Witt N, Wong TY, Hughes AD, Chaturvedi N, Klein BE, Evans R, et al. Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension. 2006;47(5):975-81. DOI: https://doi.org/10.1161/01.HYP.0000216717.72048.6c20.
Goldman D, Popel AS. A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport. J Theor Biol. 2000;206(2):181-94. DOI: https://doi.org/10.1006/jtbi.2000.211321.
Risau W. Mechanisms of angiogenesis. Nature. 1997;386(6626):671-4. DOI: https://doi.org/10.1038/386671a022.
. Hughes S, Yang H, Chan-Ling T. Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci. 2000;41(5):1217-28. Disponible en: PMID:10752963
Patton N, Aslam T, MacGillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anatomy. 2005;206(4):319-48. DOI: https://doi.org/10.1111/j.1469-7580.2005.00395.x24.
Liew G, Wang JJ. Manifestaciones vasculares retinianas: ¿reflejan el estado del corazón? Revista Española de Cardiología. 2011;64(6):515-21. DOI: doi.org/10.1016/j.recesp.2011.02.014
McGeechan K, Liew G, Macaskill P, Irwig L, Klein R, Sharrett AR, et al. Risk Prediction of Coronary Heart Disease Based on Retinal Vascular Caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). The American Journal of Cardiology. 2008;102(1):58-63. DOI: https://doi.org/10.1016/j.amjcard.2008.02.09426.
Wang JJ, Liew G, Wong TY, Smith W, Klein R, Leeder SR, et al. Retinal vascular calibre and the risk of coronary heart disease-related death. Heart. 2006;92(11):1583-7. DOI: https://doi.org/10.1136/hrt.2006.09052227.
Bairey Merz CN, Shaw LJ, Reis SE, Bittner V, Kelsey SF, Olson M, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study. Journal of the American College of Cardiology. 2006;47(3):S21-9. DOI: https://doi.org/10.1016/j.jacc.2004.12.08428.
Buchthal SD, den Hollander JA, Merz CNB, Rogers WJ, Pepine CJ, Reichek N, et al. Abnormal Myocardial Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy in Women with Chest Pain but Normal Coronary Angiograms. N Engl J Med. 2000;342(12):829-35. DOI: https://doi.org/10.1056/NEJM20000323342120129.
Kim Y, Cho JS, Cho W, Yoon HE, Hong YA, Chang YK, et al. Retinopathy and left ventricular hypertrophy in patients with chronic kidney disease: Interrelationship and impact on clinical outcomes. International Journal of Cardiology. diciembre de 2017;249:372-6. DOI: https://doi.org/10.1016/j.ijcard.2017.06.12330.
Tikellis G, Arnett DK, Skelton TN, Taylor HW, Klein R, Couper DJ, et al. Retinal Arteriolar Narrowing and Left Ventricular Hypertrophy in African Americans. The Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Hypertension. 2008;21(3):352-9. DOI: https://doi.org/10.1038/ajh.2007.5731.
Wong TY. Retinopathy and Risk of Congestive Heart Failure. JAMA. 2005;293(1):63. DOI: https:// doi.org/10.1001/jama.293.1.6332.
Benigni A, Cassis P, Remuzzi G. Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med. 2010;2(7):247-57. DOI: https://doi.org/10.1002/emmm.20100008033.
Wang J, Zhao M, Li S, Wang D. Retinal artery lesions and long-term outcome in Chinese patients with acute coronary syndrome. Eye. 2015;29(5):643-8. DOI: https://doi.org/10.1038/eye.2015.234.
Kolman SAM, van Sijl AM, van der Sluijs FA, van de Ree MA. Consideration of hypertensive retinopathy as an important end-organ damage in patients with hypertension. J Hum Hypertens. 2017;31(2):121-5. DOI: https://doi.org/10.1038/jhh.2016.4935.
Yucel O. The association between endothelial dysfunction and hypertensive retinopathy in essential hypertension. Med Sci Monit. 2014;20:78-82. DOI: https://doi.org/10.12659/MSM.88965936.
Coban E, Nizam I, Topal C, Akar Y. The Association of Low-Grade Systemic Inflammation with Hypertensive Retinopathy. Clinical and Experimental Hypertension. 2010;32(8):528-31. DOI: https:// doi.org/10.3109/10641963.2010.49651937. .
Coban E, Alkan E, Altuntas S, Akar Y. Serum ferritin levels correlate with hypertensive retinopathy. Med Sci Monit. febrero de 2010;16(2):CR92-95. Disponible en: PMID: 20110920
Varghese M, Adhyapak SM, Thomas T, Sunder M, Varghese K. The association of severity of retinal vascular changes and cardiac remodelling in systemic hypertension. Therapeutic Advances in Cardiovascular Disease. 2016;10(4):224-30. DOI: https://doi.org/10.1177/175394471663086939.
Cuspidi C, Sala C, Grassi G. Updated classification of hypertensive retinopathy: which role for cardiovascular risk stratification? Journal of Hypertension. 2015;33(11):2204-6. DOI: https://doi.org/10.1097/HJH.000000000000073340.
Sairenchi T, Iso H, Yamagishi K, Irie F, Okubo Y, Gunji J, et al. Mild Retinopathy Is a Risk Factor for Cardiovascular Mortality in Japanese With and Without Hypertension: The Ibaraki Prefectural Health Study. Circulation. 2011;124(23):2502-11. DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.04996541.
Wong TY, Cheung N, Islam FMA, Klein R, Criqui MH, Cotch MF, et al. Relation of Retinopathy to Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology. 2007;167(1):51-8. DOI: https://doi.org/10.1093/aje/kwm25642.