Dueñaz-Díaz IG, Morelos-Guzmán M, Aréan-Martínez CA, Dueñaz-Díaz JE, Chora-Hernández LD

Language: English
References: 8
Page: 80-84
PDF size: 1604.35 Kb.

ABSTRACT

Human immunodeficiency virus (HIV) infection continues to be a major public health problem. However, people living with HIV are surviving to older ages and are presenting with a higher prevalence of cardiovascular disease. HIV infection itself is associated with an increased risk of atherosclerotic cardiovascular disease, most commonly manifesting as acute coronary syndrome, typically at younger ages and often in the absence of traditional cardiovascular risk factors. We present the case of a patient with ST-segment elevation acute coronary syndrome with a history of non-significant tobacco exposure (0.75 pack-years, discontinued six years prior), whose main cardiovascular risk factor was a recent diagnosis of HIV infection. Consequently, this was a treatment-naïve patient with no prior exposure to antiretroviral therapy, consistent with findings from other studies analyzing this population, which describe a low burden of comorbidities, a distinct clinical presentation of the syndrome, and a high thrombus burden at the level of the culprit plaque on coronary angiography.

REFERENCES

1. World Health Organization. HIV statistics, globallyand by WHO region, 2025. Geneva: World HealthOrganization; 2025. (WHO/UCN/HHS/SIA/2025.03).[Accessed 24 Nov 2025] Available in: https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hiv/strategic-information/hiv-data-and-statistics

2. Dirajlal-Fargo S, Funderburg N. HIV and cardiovasculardisease: the role of inflammation. Curr Opin HIV AIDS.2022; 17 (5): 286-292.

3. Ntsekhe M, Baker JV. Cardiovascular disease amongpersons living with HIV: new insights into pathogenesisand clinical manifestations in a global context.Circulation. 2023; 147 (1): 83-100.

4. Boccara F, Lang S, Meuleman C, Ederhy S, Mary-KrauseM, Costagliola D et al. HIV and coronary heart disease:time for a better understanding. J Am Coll Cardiol.2013; 61: 511-523.

5. Sinha A, Feinstein MJ. Coronary artery diseasemanifestations in HIV: what, how, and why. Can JCardiol. 2019; 35 (3): 270-279.

6. Becker AC, Sliwa K, Stewart S, Libhaber E, Essop AR,Zambakides CA et al. Acute coronary syndromes intreatment-naïve black South Africans with humanimmunodeficiency virus infection. J Interv Cardiol.2010; 23: 70-77.

7. Fitch KV, Fulda ES, Grinspoon SK. Statins for primarycardiovascular disease prevention among people withHIV: emergent directions. Curr Opin HIV AIDS. 2022;17 (5): 293-300.

8. Mach F, Koskinas KC, Roeters van Lennep JE,Tokgozoglu L; ESC/EAS Scientific Document Group.2025 Focused Update of the 2019 ESC/EAS Guidelinesfor the management of dyslipidaemias. Eur Heart J.2025; 46 (42): 4359-4378.