medigraphic.com
SPANISH

Revista ADM Órgano Oficial de la Asociación Dental Mexicana

ISSN 0001-0944 (Print)
Órgano Oficial de la Asociación Dental Mexicana
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
    • Send manuscript
  • Políticas
    • Políticas de acceso abierto
    • Políticas de revisión de manuscritos
    • Políticas editoriales generales
    • Políticas éticas
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2026, Number 3

<< Back

Rev ADM 2026; 83 (3)

Necrotizing sialometaplasia of the hard palate.

Vera-Díaz KS, Pedraza-Jiménez J, Aldape-Barrios BC
Full text How to cite this article 10.35366/123433

DOI

DOI: 10.35366/123433
URL: https://dx.doi.org/10.35366/123433

Language: Spanish
References: 18
Page: 178-182
PDF size: 2465.07 Kb.


Key words:

necrotizing sialometaplasia, salivary glands, metaplasia.

ABSTRACT

Necrotizing sialometaplasia is a rare condition affecting the palatine minor salivary glands. Clinically, it can be confused with other malignant entities. We present the case of a 40-year-old woman with a history of rheumatoid arthritis who was on Tocilizumab (Actemra) for 10 years. Examination revealed two asymptomatic medial palatal swellings, with a 10-mm ulcer on the left side, with several weeks of evolution. After imaging studies and an incisional biopsy, a diagnosis of necrotizing sialometaplasia was established. This case presentation may help clinicians consider this entity in the differential diagnosis of palatal lesions; it highlights the importance of a good histopathological diagnosis to rule out other entities, preventing radical treatments.


REFERENCES

  1. Abrams AM, Melrose RJ, Howell FV. Necrotizing sialometaplasia. A disease simulating malignancy. Cancer. 1973 Jul;32(1):130-5. doi: 10.1002/1097-0142(197307)32:1<130::aid-cncr2820320118>3.0.co;2-8.

  2. Dunlap CL, Barker BF. Necrotizing sialometaplasia. Report of five additional cases. Oral Surg Oral Med Oral Pathol. 1974; 37 (5): 722-727. doi: 10.1016/0030-4220(74)90137-6.

  3. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 5ta Edición. Elsevier; 2023. p. 477-479.

  4. Pulse CL, Lebovics RS, Zegarelli DJ. Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. J Oral Maxillofac Surg. 2000; 58 (12): 1419-1421. doi: 10.1053/joms.2000.18280.

  5. Demiroz AS, Demirkesen C, Arslan H. Necrotizing sialometaplasia after lower lip wedge resection. Cumhuriyet Med J. 2014; 36: 397-399. doi: 10.7197/1305-0028.17133.

  6. Leonardi N, Cock DS, Sambuelli G, Gutiérrez-Magaldi I, Panico RL. Sialometaplasia necrotizante: presentación de un caso, dificultades de diagnóstico y revisión de la bibliografía. Methodo Investig Apl Las Cienc Biol. 2021; 6 (4): 194-198. doi: 10.22529/me.2021.6(4)08.

  7. Kaplan I, Alterman M, Kleinman S, Reiser V, Shuster A, Dagan Y et al. The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 114 (5): 577-585. doi: 10.1016/j.oooo.2012.02.020.

  8. Sook-Bin W. Oral Pathology. A comprehensive atlas and text. 2da Edición. Elsevier; 2017. p. 304.

  9. Allon I, Kaplan I, Allon DM, Vered H, Shlomi B, Hirshberg A. HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. Oral Dis. 2014; 20 (5): 440-445. doi: 10.1111/odi.12149.

  10. Yoshimoto S, Yada N, Ishikawa A, Kawano K, Matsuo K, Hiraki A et al. Hypoxia contributes to the early-stage progression of necrotizing sialometaplasia. Am J Pathol. 2025; 195 (6): 1074-1084. doi: 10.1016/j.ajpath.2025.01.015.

  11. Zhurakivska K, Maiorano E, Nocini R, Mignogna MD, Favia G, Troiano G et al. Necrotizing sialometaplasia can hide the presence of salivary gland tumors: a case series. Oral Dis. 2019; 25 (4): 1084-1090. doi: 10.1111/odi.13066.

  12. WHO. Head and neck tumours classification. Volume 9. 5th Edition; 2024.

  13. Dadfarnia T, Mohammed BS, Eltorky MA. Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. UTMB Health Research Expert Profiles. Disponible en: https://researchexperts.utmb.edu/en/publications/significance-of-ki-67-and-p53-immunoexpression-in-the-differentia/fingerprints/

  14. Babichenko II, Rabinovich OF, Ivina AA, Semkin VA. Immunohistochemical diagnosis of necrotizing sialometaplasia. Stomatologiia (Mosk). 2020; 99 (5): 92-95. doi: 10.17116/stomat20209905192.

  15. Imbery TA, Edwards PA. Necrotizing sialometaplasia: literature review and case reports. J Am Dent Assoc. 1996; 127 (7): 1087-1092.

  16. Gatti A, Broccardo E, Poglio G, Benech A. Necrotizing sialometaplasia of the hard palate in a patient treated with topical nonsteroidal anti-inflammatory drug. Case Rep Dent. 2016; 2016: 9545861. doi: 10.1155/2016/9545861.

  17. Ghali S, Knox KR, Verbesey J, Scarpidis U, Izadi K, Ganchi PA. Effects of lidocaine and epinephrine on cutaneous blood flow. J Plast Reconstr Aesthet Surg. 2008 Oct;61(10):1226-31. doi: 10.1016/j.bjps.2007.09.011.

  18. Actemra, Tocilizumab, información para el profesional. Basilea Suiza. 2022. Disponible en: https://assets.roche.com/f/173824/x/83e5fac347/prospecto_actemra_iv_prof.pdf




Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
CC BY-NC-ND

2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev ADM. 2026;83