Macías-Rivera AV, Monroy-Colín VA, Delgadillo-Castañeda R

Language: Spanish
References: 6
Page: 27-30
PDF size: 638.81 Kb.

ABSTRACT

Introduction: Clostridioides difficile infection (CDI) is a growing cause of pediatric morbidity, especially in children with chronic comorbidities. Objective: to identify risk factors, prevalence, and morbidity and mortality associated with CDI in the pediatric population of Centenario Hospital Miguel Hidalgo. Material and methods: observational, analytical and retrospective case-control study (n = 154) in patients under 18 years of age with acute diarrhea evaluated by multiplexed PCR (FilmArray ^®) between 2021 and 2025. Results: 77 cases and 77 controls were included. No significant differences were found in prior antibiotic use (p = 0.316). Oncological comorbidities (48.8 vs. 21.4%) and heart disease (17.1 vs. 4.8%) were significantly more frequent in cases (p = 0.037). A positive GDH antigen was associated with the presence of toxins (OR = 15.22, p = 0.0018). Conclusions: CDI is mainly associated with specific comorbidities (oncological and cardiac).

REFERENCES

1. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE et al. Clinical practice guidelines for clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018; 66 (7): e1-48.

2. Schutze GE, Willoughby RE; Committee on Infectious Diseases; American Academy of Pediatrics. Clostridium difficile infection in children. Pediatrics. 2013; 131 (1): 196-200.

3. Linares-López KA. Características clínicas y epidemiológicas de la infección por Clostridioides difficile en pacientes pediátricos del Instituto Nacional de Pediatría 2013-2018 [Tesis]. Ciudad de México: Universidad Nacional Autónoma de México; 2019.

4. Wendt JM, Cohen NJ, Mu Y, Netoskie MA, Thompson AD, Samarce VG et al. Clostridium difficile infection in children: a report from the National Institute of Allergy and Infectious Diseases. J Pediatric Infect Dis Soc. 2019; 8 (3): 251-259.

5. Santiago B, Rusiñol M, Martín V et al. Aislamiento de Clostridium difficile en niños hospitalizados con diarrea. An Pediatr (Barc). 2015; 83 (6): 397-404.

6. Molina-Vallejo LE. Prevalencia de infección asociada a la atención de la salud por Clostridioides difficile en el Instituto Nacional de Pediatría 2017-2022 [Tesis]. Ciudad de México: Universidad Nacional Autónoma de México; 2024.