Zúñiga CIR, Caro LJ

Language: Spanish
References: 5
Page: 31-34
PDF size: 629.37 Kb.

ABSTRACT

Obelisks form a distinct phylogenetic group restricted to RNA datasets. They lack obvious homology with previously characterized genomes or viromes. Obelisk RNA reads assemble into circles of approximately 1,000 nucleotides. These circles adopt rod-shaped RNA secondary structures and encode at least one member of a novel protein superfamily, termed "Oblin". Furthermore, a subset of obelisks was found to harbor obelisk-specific hammer-like ribozyme motifs. Obelisks are globally distributed and possibly overrepresented in mammalian datasets, and constitute a distinct and diverse group of phylogenetically related RNA elements.

REFERENCES

1. Zheludev IN, Edgar RC, Lopez-Galiano MJ, de la Peña M, Babaian A, Bhatt AS, Fire AZ. Viroid-like colonists of human microbiomes. Cell. 2024; 187 (23): 6521-6536.e18.

2. Maddamsetti R, You L. Circular RNA Obelisk-S.s is highly abundant in Streptococcus sanguinis SK36. bioRxiv. 2024.03.24.586467

3. López J, de la Peña M, Martínez M. Viroid-like "obelisk" agents are widespread in the ocean and exceed the abundance of RNA viruses in the prokaryotic fraction. The ISME Journal. 2025; 19 (1): wraf033.

4. Li L, Zhang X, Wu M. A novel viroid-like RNA element "Obelisks": a major breakthrough in the RNA World. Mol Biomed. 2025; 6: 47.

5. Wu M, Li W, Hu N, Liu C, Li J et al. Discovery of a novel viroid-like circular RNA in colorectal cancer. Cancer Commun (Lond). 2025; 45: 46-50.