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2026, Number 4

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Acta Med 2026; 24 (4)

Post-COVID-19 avascular necrosis of the femoral head

Sáenz GMC, De los Santos MFA
Full text How to cite this article 10.35366/123509

DOI

DOI: 10.35366/123509
URL: https://dx.doi.org/10.35366/123509

Language: Spanish
References: 5
Page: 439-441
PDF size: 1107.93 Kb.


Key words:

COVID-19, avascular necrosis of the femoral head, corticosteroids, SARS-CoV-2, total hip replacement.

ABSTRACT

Avascular necrosis (AVN) of the hip is a condition characterized by the progressive loss of bone viability due to vascular abnormalities, affecting the trabecular architecture of the bone. Among the classic risk factors is prolonged use of corticosteroids, which has been widely documented as a cause of AVN. Beginning in 2019, with the appearance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an increase in cases of AVN was identified in post-COVID patients, including those without a clear history of prolonged steroid therapy. It has been hypothesized that the inflammatory and hypercoagulable state induced by infection with the 2019 coronavirus disease (COVID-19) could contribute to the disruption of intraosseous blood flow, promoting necrosis. However, current evidence remains limited and does not allow for the establishment of a definitive causal relationship between SARS-CoV-2 infection and the development of AVN. The aim of this study is to analyze whether there is a significant association between the post-COVID state and the appearance of avascular necrosis, considering both inflammatory and therapeutic factors (steroid use), based on the literature available to date.


REFERENCES

  1. Pijnenburg L, Felten R, Javier RM. Ostéonécroses aseptiques, unerevue générale des ostéonécroses de la hanche, et au-delà [A reviewof avascular necrosis, of the hip and beyond]. Rev Med Interne. 2020;41 (1):27-36.

  2. Disser NP, De Micheli AJ, Schonk MM et al. Musculoskeletalconsequences of COVID-19. J Bone Joint Surg Am. 2020; 102 (14):1197-1204.

  3. Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosisand clinical manifestations of steroid-induced osteonecrosis. JAutoimmun. 2020; 110: 102460.

  4. Auyeung TW, Lee JS, Lai WK et al. The use of corticosteroidas treatment in SARS was associated with adverse outcomes: aretrospective cohort study. J Infect. 2005; 51 (2): 98-102.

  5. Hassan AAA, Khalifa AA. Femoral head avascular necrosis in COVID-19survivors: a systematic review. Rheumatol Int. 2023; 43: 1583-1595.




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C?MO CITAR (Vancouver)

Acta Med. 2026;24