medigraphic.com
ISSN 3061-8142 (Electronic)

2026, Number 3

<< Back Next >>

Rev Mex Anest 2026; 49 (3)

Fibromyalgia: a scooping review

Covarrubias-Gómez A, Carrillo-Torres O, Esquer-Guzmán HM, Guzmán-Rullan P, Sánchez-Diaz J, Vicente-Mendoza M

Language: Spanish
References: 35
Page: 187-192
PDF size: 923.23 Kb.


ABSTRACT

Introduction: fibromyalgia is a central sensitization syndrome that affects 2 to 8% of the world's population. We conducted a scoping review of the literature on the topic with the aim of promoting a conceptual and therapeutic update. Material and methods: documents with the word "fibromyalgia" in the title were identified in the PubMed database. Meta-analyses and systematic reviews published within the last five years were selected. Results: the results of the 142 identified documents were divided into sections related to the syndrome concept, pathophysiology, diagnosis, and therapeutic considerations. Conclusions: the conceptualization of fibromyalgia has undergone conceptual, diagnostic, and therapeutic changes. This syndrome has been underestimated and unattended. An updating on the topic for health providers is required.


REFERENCES

  1. Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update. Int J Mol Sci. 2021;22:3891. doi: 10.3390/ijms22083891.

  2. Dizner-Golab A, Lisowska B, Kosson D. Fibromyalgia - etiology, diagnosis and treatment including perioperative management in patients with fibromyalgia. Reumatologia. 2023;61:137-148. doi: 10.5114/reum/163094.

  3. Iannuccelli C, Favretti M, Dolcini G, Di Carlo M, Pellegrino G, Bazzichi L, et al. Fibromyalgia: one year in review 2025. Clin Exp Rheumatol. 2025;43:957-969. doi: 10.55563/clinexprheumatol/buhd2z.

  4. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, et al. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat. 2012;2012:426130. doi: 10.1155/2012/426130.

  5. Covarrubias-Gómez A, Carrillo-Torres O. Actualidades conceptuales sobre fibromialgia. Rev Mex Anest. 2016;39:58-63.

  6. Clauw DJ. From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here? Ann Rheum Dis. 2024;83:1421-1427. doi: 10.1136/ard-2023-225327.

  7. Mak S, Thomas A. Steps for conducting a scoping review. J Grad Med Educ. 2022;14:565-567. doi: 10.4300/JGME-D-22-00621.1.

  8. Benjamin NZY, Parekh RS, Inban P, Sakthi S, Tekuru Y, Prajjwal P, et al. Fibromyalgia: advances in pathophysiology, diagnostic biomarkers, genetic insights, multisystemic involvement, and treatment updates and multidisciplinary interventions. Dis Mon. 2025;71:101965. doi: 10.1016/j.disamonth.2025.101965.

  9. Neblett R, Cohen H, Choi Y, Hartzell MM, Williams M, Mayer TG, et al. The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample. J Pain. 2013;14:438-445. doi: 10.1016/j.jpain.2012.11.012.

  10. Findeisen K, Guymer E, Littlejohn G. Neuroinflammatory and immunological aspects of fibromyalgia. Brain Sci. 2025;15:206. doi: 10.3390/brainsci15020206.

  11. Aloisi AM, Casini I. Fibromyalgia: chronic pain due to a blood dysfunction? Int J Mol Sci. 2025;26:4153. doi: 10.3390/ijms26094153.

  12. Marshall A, Elshafei M, Preston FG, Burgess J, Goodson N, Fallon N, et al. Small fibre pathology in fibromyalgia: a review. Pain Ther. 2025;14:461-478. doi: 10.1007/s40122-024-00696-1.

  13. García-Domínguez M. Role of the endocannabinoid system in fibromyalgia. Curr Issues Mol Biol. 2025;47:230. doi: 10.3390/cimb47040230.

  14. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RL, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46:319-329. doi: 10.1016/j.semarthrit.2016.08.012.

  15. Nijs J, Lahousse A, Kapreli E, Bilika P, Saracoglu I, Malfliet A, et al. Nociplastic pain criteria or recognition of central sensitization? Pain phenotyping in the past, present and future. J Clin Med. 2021;10:3203. doi: 10.3390/jcm10153203.

  16. Filipovic T, Filipovic A, Nikolic D, Gimigliano F, Stevanov J, Hrkovic M, et al. Fibromyalgia: understanding, diagnosis and modern approaches to treatment. J Clin Med. 2025;14:955. doi: 10.3390/jcm14030955.

  17. Ram PR, Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Khanna M, Gupta A, et al. Beyond the pain: a systematic narrative review of the latest advancements in fibromyalgia treatment. Cureus. 2023;15:e48032. doi: 10.7759/cureus.48032.

  18. Migliorini F, Maffulli N, Eschweiler J, Baroncini A, Bell A, Colarossi G. Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis. J Orthop Surg Res. 2023;18:504. doi: 10.1186/s13018-023-03995-z.

  19. Barrot M, Basile HP, Kremer M. Monoamine-uptake inhibitors and pain: antidepressant drugs among first-line treatments against neuropathic pain and fibromyalgia. Adv Neurobiol. 2025;46:293-315. doi: 10.1007/978-3-031-96364-3_12.

  20. Devigili G, Di Stefano G, Donadio V, Frattale I, Grazzi L, Mantovani E, et al. Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian Neurological Society. Neurol Sci. 2025;46:2263-2288. doi: 10.1007/s10072-025-08048-3.

  21. Moore A, Bidonde J, Fisher E, Hauser W, Bell RF, Perrot S, et al. Effectiveness of pharmacological therapies for fibromyalgia syndrome in adults: an overview of Cochrane Reviews. Rheumatology (Oxford). 2025;64:2385-2394. doi: 10.1093/rheumatology/keae707.

  22. Strand NH, Maloney J, Kraus M, Wie C, Turkiewicz M, Gomez DA, et al. Cannabis for the treatment of fibromyalgia: a systematic review. Biomedicines. 2023;11:1621. doi: 10.3390/biomedicines11061621.

  23. Abolhosseini S, Malatesta A, Asmundson AJN, Gilron I, Salomons TV. Analgesic benefits of pharmacological and nonpharmacological sleep interventions for adults with fibromyalgia: a systematic review and meta-analyses. Pain. 2025;166:2698-2720. doi: 10.1097/j.pain.0000000000003708.

  24. Megía-García Á, Serrano-Muñoz D, Bravo-Esteban E, Ando-Lafuente S, Avendaño-Coy J, Gómez-Soriano J. Efectos analgésicos de la estimulación eléctrica nerviosa transcutánea en pacientes con fibromialgia: una revisión sistemática. Aten Primaria. 2019;51:406-415. doi: 10.1016/j.aprim.2018.03.010.

  25. Winterholler C, Coura MH, Montoya P. Clinical, neurophysiological and neurochemical effects of non-invasive electrical brain stimulation in fibromyalgia syndrome-a systematic review and meta-analysis. Front Pain Res (Lausanne). 2025;6:1593746. doi: 10.3389/fpain.2025.1593746.

  26. Miller EE, Jayakrishnan S, Froio F, Ahmed D, Haq H, Schnurer S, et al. Mediterranean diet and its low-antigenic and anti-inflammatory properties on fibromyalgia: a systematic review. Clin Exp Rheumatol. 2025;43:970-977. doi: 10.55563/clinexprheumatol/2usk4p.

  27. Dipalma G, Marinelli G, Ferrante L, Di Noia A, Carone C, Colonna V, et al. Modulating the gut microbiota to target neuroinflammation, cognition and mood: a systematic review of human studies with relevance to fibromyalgia. Nutrients. 2025;17:2261. doi: 10.3390/nu17142261.

  28. Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B. Nutritional interventions in the management of fibromyalgia syndrome. Nutrients. 2020;12:2525. doi: 10.3390/nu12092525.

  29. Sosa-Reina MD, Nunez-Nagy S, Gallego-Izquierdo T, Pecos-Martín D, Monserrat J, Álvarez-Mon M. Effectiveness of therapeutic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomized clinical trials. Biomed Res Int. 2017;2017:2356346. doi: 10.1155/2017/2356346.

  30. Rodríguez-Huguet M, Ayala-Martínez C, Góngora-Rodríguez P, Rosety-Rodríguez MÁ, Martín-Valero R, Góngora-Rodríguez J. Aquatic exercise in physical therapy treatment for fibromyalgia: systematic review. Healthcare (Basel). 2024;12:701. doi: 10.3390/healthcare12060701.

  31. Busch AJ, Webber SC, Richards RS, Bidonde J, Schachter CL, Schafer LA, et al. Resistance exercise training for fibromyalgia. Cochrane Database Syst Rev. 2013;2013:CD010884. doi: 10.1002/14651858.CD010884.

  32. Albuquerque MLL, Monteiro D, Marinho DA, Vilarino GT, Andrade A, Neiva HP. Effects of different protocols of physical exercise on fibromyalgia syndrome treatment: systematic review and meta-analysis of randomized controlled trials. Rheumatol Int. 2022;42:1893-1908. doi: 10.1007/s00296-022-05140-1.

  33. Couto N, Monteiro D, Cid L, Bento T. Effect of different types of exercise in adult subjects with fibromyalgia: a systematic review and meta-analysis of randomised clinical trials. Sci Rep. 2022;12:10391. doi: 10.1038/s41598-022-14213-x.

  34. Núñez-Cortés R, Suso-Martí L, Almonacid-Lleida J, Salazar-Méndez J, López-Bueno R, Cruz-Montecinos C, et al. Optimal dose of aerobic exercise programs to reduce pain intensity and improve health status in patients with fibromyalgia: a dose-response meta-analysis. Phys Ther. 2025;105:pzaf057. doi: 10.1093/ptj/pzaf057.

  35. Lee SY, Song K, Rathore FA. Rehabilitation of adults with fibromyalgia. J Pak Med Assoc. 2025;75:1309-1311. doi: 10.47391/JPMA.25-67.




2020     |     www.medigraphic.com