2026, Number 1
<< Back Next >>
Dermatología Cosmética, Médica y Quirúrgica 2026; 24 (1)
Alopecia areata: maintenance treatment with simvastatin and ezetimibe, usage experience
Zapata GA, Morales CKJ
Language: Spanish
References: 11
Page: 83-88
PDF size: 356.45 Kb.
ABSTRACT
Alopecia areata is an immune-mediated disorder characterized
by non-scarring hair loss involving the scalp and
other body areas. Its management remains challenging
due to a limited therapeutic armamentarium and variable
response rates. Statins, commonly used in cardiovascular
disease prevention, exhibit immunomodulatory properties
that have prompted interest in their potential role in selected
dermatologic conditions, including alopecia areata. We
present our clinical experience with the use of oral simvastatin
combined with ezetimibe as an adjunctive treatment
in patients with alopecia areata, within a therapeutic
approach that is still under clinical exploration.
REFERENCES
Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J.Alopecia areata update. Part I. Clinical picture, histopathology,and pathogenesis. J Am Acad Dermatol. febrero de 2010;62(2):177–88.
Pratt CH, King LE, Messenger AG, Christiano AM, Sundberg JP.Alopecia areata. Nat Rev Dis Primers. el 16 de marzo de 2017;3.
Greenwood J, Steinman L, Zamvil SS. Statin therapyand autoimmune disease: From protein prenylation toimmunomodulation. Nat Rev Immunol. mayo de 2006;6(5):358–70.
Lattouf C, Jimenez JJ, Tosti A, Miteva M, Wikramanayake T,Kittles C. Tratamiento de alopecía areata con Simvastatina/Ezetimibe. J Am Acad Dermatol. 2015;
Sibbald C. Alopecia Areata: An Updated Review for 2023. Vol.27, Journal of Cutaneous Medicine and Surgery. 2023.
Cervantes J, Jimenez JJ, DelCanto GM, Tosti A. Treatment ofAlopecia Areata with Simvastatin/Ezetimibe. Vol. 19, Journal ofInvestigative Dermatology Symposium Proceedings. ElsevierB.V.; 2018. p. S25–31.
Morgado-Carrasco D, Rodríguez-Lobato E, Riera-Monroig J,Ferrando J. The Good and Bad News About New Drugs forTreating Alopecia Areata. Actas Dermosifiliogr. el 1 de enero de2018;109(1):69–70.
Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R. Hairfollicle immune privilege and its collapse in alopecia areata. ExpDermatol. el 1 de agosto de 2020;29(8):703–25.
Jiang JL, Wang S, Li NS, Zhang XH, Deng HW, Li YJ. Theinhibitory effect of simvastatin on the ADMA-inducedinflammatory reaction is mediated by MAPK pathways inendothelial cells. Biochemistry and Cell Biology. febrero de2007;85(1):66–77.
Choi JW, Suh DW, Lew BL, Sim WY. Simvastatin/ezetimibetherapy for recalcitrant alopecia areata: An open prospectivestudy of 14 patients. Ann Dermatol. el 1 de diciembre de2017;29(6):755–60.
Freitas Gouveia M, Trüeb RM. Unsuccessful Treatment ofAlopecia Areata with Simvastatin/Ezetimibe: Experiencein 12 Patients. Skin Appendage Disord. el 1 de agosto de2017;3(3):156–60.