Sánchez GSA

Language: Spanish
References: 5
Page: 1-6
PDF size: 419.61 Kb.

ABSTRACT

OBJECTIVE: To report the hematological neoplasms affecting patients and their firstdegree relatives in the last 27 years of private practice.
MATERIALS AND METHODS: A retrospective, observational and descriptive study in which all mestizo patients with hematologic malignancies whose first-degree relatives were also affected by any kind of hematologic neoplasia were censored. Familial hematologic neoplasia was considered if two or more first-degree relatives were affected.
RESULTS: Out of 952 patients who attended the outpatient Hematology clinic, 130 had a malignant neoplasia, whereas 8 (6.1%) patients had a first-degree relative with a similar or another malignant blood disease. Affected relatives included: parents, siblings or children by diseases such as multiple myeloma (4 cases), non-Hodgkin lymphoma (4 cases), chronic lymphocytic leukemia (4 cases), acute myeloid leukemia (2 cases), Hodgkin’s lymphoma (2 cases), acute leukemia (1 case) and leukemia non-specified (1 case), for a total of 18 sick persons in 8 different families. A mendelian inheritance pattern was found. In two different families the so-called anticipation phenomenon was evident.
CONCLUSIONS: It is important to identify this kind of familial hematologic neoplasm pattern in order to give a genetic counseling as well as a closer follow-up in patients and relatives in risk to develop a similar disease which permits an early diagnosis and treatment.

REFERENCES

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