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ISSN 1561-3011 (Electronic)

2022, Number 1

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Rev Cubana Invest Bioméd 2022; 41 (1)

Neuro-epidemiological evaluation from memory antiviral antibodies generated by the mmr vaccine

Castillo GW, Cruz QM, Dorta CAJ

Language: Spanish
References: 19
Page: 1-16
PDF size: 313.54 Kb.


ABSTRACT

Introduction: The measles-mumps-rubella vaccine is administered in Cuba with 99% vaccination coverage. Currently, the low immunogenicity of the strain of mumps with which it is manufactured is raised, so it is important to ensure the effectiveness of vaccines and their protective immune response.
Objectives: Evaluate the behavior of the anti-rubella, anti-mumps and anti-measles antibody indices according to age, and to analyze the variation of the anti-mumps antibody response with respect to previous studies.
Materials and methods: Serum and cerebro-spinal fluid samples from 42 pediatric patients with neuro-inflammatory processes were studied and total IgG and albumin and specific antibodies against the three viruses were quantified from immunoenzymatic assays ELISA type. Corresponding reibergrams and specific antibody indices were performed.
Results: A sustained increase in antibodies against the ethree immunogens was observed in general, without significant differences due to age or notable post-vaccination changes. There was a decrease in the antibody index as it moved away from the date of revaccination, so surveillance should be maintained in these age groups. The rate of production of anti-mumps antibodies was higher than against the other viruses, although not significantly.
Conclusions: This vaccine guarantees protection by the uniformity of the memory induced immune response in all age groups. An increase in the protection of the studied population against mumps was demonstrated with respect to previous studies.


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