2003, Number 2
Med Sur 2003; 10 (2)
Vera-Izaguirre DS, Chávez-Tapia NC, Lizardi-Cervera J, Méndez-Sánchez N
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ABSTRACTThe infectious mononucleosis (IM) etiology its attributed to several virus, mainly Epstein-Barr virus (EBV), discovered by Epstein, Achong and Barr 36-years ago. EBV has been associated to malignancy in patients with immunodeficiency. Its prevalence is higher than 90% and maintain persistent infection; its very common in young adults and adolescents. Acute illness is characterized clinically by sore throat, fever, and lymphadenopathy; in serology there are heterophile antibody, in peripherical blood are leucocytes with atypical monocytes. Potential complications are hemolytic anemia, thrombocytopenic purpura, and rarely hemophagocytic syndrome and splenic rupture. Neurologic symptoms, lung and cardiac manifestations could be founded in IM, until airway obstruction. Treatment of EBV-associated acute IM is primarily supportive. Acyclovir is useful to treat oral hairy leukoplakia; other antivirals are useful too. Corticosteroids utilities are controversial. Prevention with vaccine is recommended in transplant receptors, patients with lymphoproliferative syndromes associated to X and endemic population of Burkitt lymphomas and nasopharyngeal carcinoma.