Médica Sur

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Médica Sur >Year 2003, Issue 2

Vera-Izaguirre DS, Chávez-Tapia NC, Lizardi-Cervera J, Méndez-Sánchez N
Infectious mononucleosis
Med Sur 2003; 10 (2)

Language: Espańol
References: 16
Page: 76-89
PDF: 136.94 Kb.

Full text


The infectious mononucleosis (IM) etiology its attributed to several virus, mainly Epstein-Barr virus (EBV), discovered by Epstein, Achong and Barr 36-years ago. EBV has been associated to malignancy in patients with immunodeficiency. Its prevalence is higher than 90% and maintain persistent infection; its very common in young adults and adolescents. Acute illness is characterized clinically by sore throat, fever, and lymphadenopathy; in serology there are heterophile antibody, in peripherical blood are leucocytes with atypical monocytes. Potential complications are hemolytic anemia, thrombocytopenic purpura, and rarely hemophagocytic syndrome and splenic rupture. Neurologic symptoms, lung and cardiac manifestations could be founded in IM, until airway obstruction. Treatment of EBV-associated acute IM is primarily supportive. Acyclovir is useful to treat oral hairy leukoplakia; other antivirals are useful too. Corticosteroids utilities are controversial. Prevention with vaccine is recommended in transplant receptors, patients with lymphoproliferative syndromes associated to X and endemic population of Burkitt lymphomas and nasopharyngeal carcinoma.

Key words: Mononucleosis, Epstein-Barr virus, fever.


  1. Stratus SE, Cohen JI, Tosato G, Meier J. Epstein-Barr virus infections: biology, pathogenesis, and management. Ann Intern Med 1993; 118: 45-58.

  2. Peter J, Ray CG. Infectious mononucleosis. Pediatr Rev 1998; 19: 276-279.

  3. Schaller RJ, Counselman FL. Reviews: infectious mononucleosis in young children. Am J Emerg Med 1995; 13: 438-440.

  4. Hickey SM, Strasburger VC. What every pediatricians should know about infections mononucleosis in adolescents. Pediatr Clin North Am 1997; 44: 1541-1556.

  5. Cohen JI. Epstein-Barr Virus Infection. N Engl J Med 2000; 343: 481-492.

  6. Ikediobi NI, Tyrinng SK. Cutaneous manifestations of Epstein-Barr virus infection. Dermatol Clin 2002; 20: 283-289.

  7. Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician 2002; 66: 2103-2110.

  8. Schooley RT. Epstein-Barr Virus (Infectious Mononucleosis). In: Mandell: Principles and Practice of Infectious Diseases. 5th ed. 2000 Churchill Livingstone.

  9. Vidrih JA, Walesnsky RP, Sax PE, Freedberg KA. Positive Epstein-Barr virus heterophile antibody test in patients with primary human immunodeficiency virus infection. Am J Med 2001; 111: 192-194.

  10. Taylor GH. Cytomegalovirus. Am Fam Physician 2003; 67: 519-524.

  11. Pass RF. Cytomegalovirus Infection. Pediatr Rev 2002; 23: 163-170.

  12. Howard MJ, Brillman JC, Burkle FM Jr. Infectious disease emergencies in disasters. Emerg Med Clin North Am 1996; 14: 413-428.

  13. Yen A, Fearneyhough P, Raimer SS. EBV-associated Kikuchi´s histiocitic necrotizing limphadenitis with cutaneous manifestations. Am Acad Dermatol 1997; 36: 342-346.

  14. Simon MW. Neurologic Complications of Epstein-Barr Virus Infection. Am Fam Physician 2000; 61: 643-644.

  15. Salazard B, Paut O, Nicollas R, Zandotti C, Cheristian MA, Thuret I, Camboulives J. Severe upper airway obstruction in infectious mononucleosis: a life emergency. Arch Pediatr 2001: 952-956.

  16. Wick MJ, Woronzoff-Dashkoff KP, McGlennen RC. The molecular characterization of fatal infectious mononucleosis. Am J Clin Pathol 2002; 117: 582-588.

>Journals >Médica Sur >Year 2003, Issue 2

· Journal Index 
· Links 

Copyright 2019