2026, Number 4
<< Back Next >>
Cir Card Mex 2026; 11 (4)
Pulmonary neuroendocrine tumor: cases report
Jiménez-González RJ, Ogaz-Escarpita MC, Guillén-Ramírez RM, Marmolejo-Rivera R, García-Villarreal OA
Language: English
References: 17
Page: 166-170
PDF size: 2048.58 Kb.
ABSTRACT
Pulmonary neuroendocrine neoplasms (PEN) are defined as a
group of lung tumors that exhibit neuroendocrine morphology
and immunophenotype. They are usually slow-growing neoplasms
with nonspecific symptoms. We present two clinical cases of
PENs treated by video-assisted thoracoscopy and anterior minithoracotomy,
with subsequent specific diagnosis by histopathology
and immunohistochemistry.
REFERENCES
Ito T, Hijioka S, Masui T, et al. Advances in the diagnosis andtreatment of pancreatic neuroendocrine neoplasms in Japan. JGastroenterol. 2017;52(1):9-18. doi: 10.1007/s00535-016-1250-9.
Rindi G, Mete O, Uccella S, et al. Overview of the 2022 WHOclassification of neuroendocrine neoplasms. Endocr Pathol.2022;33(1):115-154. doi: 10.1007/s12022-022-09708-2.
Vocino TG, Righi L, Volante M, Papotti M. Updates on lungneuroendocrine neoplasm classification. Histopathology.2024;84(1):67-85. doi: 10.1111/his.15058.
Hung YP. Neuroendocrine tumors of the lung: updates and diagnosticpitfalls. Surg Pathol Clin. 2019;12(4):1055-1071. doi: 10.1016/j.path.2019.08.012.
Karnan A. A rare neuroendocrine tumor of the lung. Pan Afr Med J.2023;46:54. doi: 10.11604/pamj.2023.46.54.41283.
Dasari A, Shen C, Halperin D, et al. Trends in the incidence,prevalence, and survival outcomes in patients with neuroendocrinetumors in the United States. JAMA Oncol. 2017;3(10):1335-1342.doi: 10.1001/jamaoncol.2017.0589
Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoidtumors. Cancer. 2003;97(4):934-959. doi: 10.1002/cncr.11105.
Tomita T. Significance of chromogranin A and synaptophysinin pancreatic neuroendocrine tumors. Bosn J Basic Med Sci.2020;20(3):336-346. doi: 10.17305/bjbms.2020.4632.
Gkolfinopoulos S, Tsapakidis K, Papadimitriou K, PapamichaelD, Kountourakis P. Chromogranin A as a valid marker in oncology:Clinical application or false hopes? World J Methodol. 2017;7(1):9-15. doi: 10.5662/wjm.v7.i1.9.
Kriegsmann K, Zgorzelski C, Muley T, et al. Role of synaptophysin,chromogranin and CD56 in adenocarcinoma and squamous cellcarcinoma of the lung lacking morphological features of neuroendocrinedifferentiation: a retrospective large-scale study on 1,170 tissue samples.BMC Cancer. 2021;21(1):486. doi: 10.1186/s12885-021-08140-9.
Moller K, Uhlig R, Gorbokon N, et al. Comparison of INSM1immunostaining with established neuroendocrine markerssynaptophysin and chromogranin A in over 14,000 neuroendocrine andnon-neuroendocrine tumors. Mol Cell Endocrinol. 2024;581:112106.doi: 10.1016/j.mce.2023.112106.
Sakakibara R, Kobayashi M, Takahashi N, et al. Insulinoma-associatedProtein 1 (INSM1) Is a Better Marker for the Diagnosis and PrognosisEstimation of Small Cell Lung Carcinoma Than Neuroendocrine PhenotypeMarkers Such as Chromogranin A, Synaptophysin, and CD56. Am J SurgPathol. 2020;44(6):757-764. doi: 10.1097/PAS.0000000000001444.
Iso H, Hisakane K, Mikami E, et al. Thyroid transcription factor-1(TTF-1) expression and the efficacy of combination therapy withimmune checkpoint inhibitors and cytotoxic chemotherapy in nonsquamousnon-small cell lung cancer. Transl Lung Cancer Res.2023;12(9):1850-1861. doi: 10.21037/tlcr-23-331.
Verset L. TTF-1 positive small cell cancers: Don’t think they’re alwaysprimary pulmonary! World J Gastrointest Oncol. 2011;3(10):144. doi:10.4251/wjgo.v3.i10.144.
Xie B, Sui T, Qin Y, Miao S, Jiao W. [Comparison of Short-termOutcomes of Lung Segmentectomy by Robotic-assisted and VideoassistedThoracoscopic Surgery]. Zhongguo Fei Ai Za Zhi ChinJ Lung Cancer. 2019;22(12):767-771. doi: 10.3779/j.issn.1009-3419.2019.12.06.
Ma J, Li X, Zhao S, Wang J, Zhang W, Sun G. Robot-assisted thoracicsurgery versus video-assisted thoracic surgery for lung lobectomy orsegmentectomy in patients with non-small cell lung cancer: a metaanalysis.BMC Cancer. 2021;21(1):498. doi: 10.1186/s12885-021-08241-5.
Kidane B, Bott M, Spicer J, et al. The American Association forThoracic Surgery (AATS) 2023 expert consensus document: stagingand multidisciplinary management of patients with early-stage nonsmallcell lung cancer. J Thorac Cardiovasc Surg. 2023;166(3):637-654. doi: 10.1016/j.jtcvs.2023.04.039.