Zavaleta M, Rosete A, Jiménez TN, Zavala-García C

Language: Spanish
References: 16
Page: 14-20
PDF size: 84.45 Kb.

ABSTRACT

Pain is considered as the fifth vital sign and is the first cause of medical consultation worldwide. The initial treatment depends of it’s intensity and should follow the guidelines proposed by the World Health Organization. About 30 million people in the world have used non-steroidal anti-inflammatory drugs, 40% of which are in the seventh decade of life. Ketorolac, was introduced in the market about a decade ago. As it’s indications began to increase rapidly, so did the adverse gastrointestinal, renal and hematologic reactions. In this article we review the information regarding ketorolac including pharmacokinetics, pharmacodynamics, indications, dosing and adverse effects.

REFERENCES

1. Rosete A, Albarran J, Barrientos A, Poo JL. Errores de medicación detectados en un estudio de utilización de antiinflamatorios no esteroides (AINES) y analgésicos en los sectores de hospitalización. En: resúmenes del 6º Congreso Anual de Médica Sur y Sociedad de Médicos A.C. Med Sur 2006; 13(2): 85-106.

2. Rocchi A. Canadian survey of postsurgical pain and pain medication experiences. Can J Anesth 2002;49(10):1053–1056.

3. http://www.who.int/cancer/palliative/painladder/en/

4. American Society of Anesthesiologists, Practice Guidelines for Acute Pain Management in the Perioperative Setting. An Updated Report by the American Society of Anesthesiologists Task Force on Acute Pain Management. Anesthesiology 2004; 100: 1573-81.

5. Macario E. Ketorolac in the era of cyclo-oxigenase-2 selective nonsteroideal anti-inflammatory drugs: a Systematic Review of Efficacy, Side effects, and Regulatory issues. Pain Medicine 2001: 4.

6. http://accessdata.fda.gov/scripts/cder/drugsatfa/

7. Micromedex® Health Care Series 2007

8. Garrote A, Bonet R. El papel de los AINES en el tratamiento analgésico. OFFARM 2003; 22(2): 56-62.

9. Ashworth H et al. The influence of timing and route of administration of intravenous ketorolac on analgesia after hand surgery. Anaesthesia 2002; 57: 535-539.

10. American Hospital Formulary Service (AHFS) Drug Information Handbook. Second Edition. Sprinhouse, PA. Lippincott Williams & Wilkins. 2003: 684-686.

11. Khan KNM et al. Pharmacology of cyclooxygenase-2 inhibition in the kidney. Kidney International 2002; 61: 1210-1219.

12. Munir M et al. Nonopioid Analgesics. Med Clin N Am 2007; 91: 97-111.

13. www.clinicalpharmacology.com/direct/getinfotext. asp?caller=esmdcF&cpnum=33

14. Linklater D et al. Painful dilemmas: An evidence-based look at challenging clinical scenarios. Emerg Med Clin North Am 2005; 23: 367-392.

15. Taber S et al. Drug-associated renal dysfunction. Crit Care Clin 2006; 22: 357-374.

16. Leung A. Postoperative pain management in obstetric anesthesia-new challenges and solutions. J Clin Anesth 2004; 16: 57-65.