Effect of S-Nitrosoglutathione (GSNO) added to the University of Wisconsin Solution (UW): Mast cell degranulation during normothermic reperfusion

Alejandra B Quintana; Joaquín V Rodríguez; Henrique L Lenzi; Edgardo E Guibert

2004, Number 3

<< Back Next >>

Ann Hepatol 2004; 3 (3)

Effect of S-Nitrosoglutathione (GSNO) added to the University of Wisconsin Solution (UW): Mast cell degranulation during normothermic reperfusion

Quintana AB, Rodríguez JV, Lenzi HL, Guibert EE

Full text

How to cite this article

Language: English
References: 0
Page: 113
PDF size: 41.60 Kb.

Text Extraction

Morphology of portal mast cells in rat liver after cold preservation/normothermic reperfusion: Rat livers were cold preserved (0°C) during 48 h in UW solution with the addition of 500 µM GSNO to improve liver preservation. GSNO is a S-nitrosothiol, which releases the vasodilator Nitric Oxide that acts on hepatic microvascular system protecting the liver from preservation/reperfusion injuries. Apart from hepatocytes and non-parenchymal cells, the resident cells, such as mast cells, appear to be involved in the pathogenesis of these injuries. Any increment in oxygen-free radicals induces mast cell degranulation and these alterations promote granulocyte infiltration during graft reperfusion in vivo.