Tiribelli C

Language: English
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Page: 143
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Alcohol intake predisposed to …. . by Maria Fatina Gomes de Sa Ribero et al

One accepted theory to explain the progression from a benign disease such as fatty liver to the more serous and irreversible liver damage as NASH/ASH is that of the “second hit”. In other terms, two noxae are more dangerous than one, particularly if they act in parallel rather than in series. The data reported by the group in São Paulo add additional evidence that this obvious but never fully experimentally proven concept is true. A quite large sample of patients with HCV-related liver damage was divided according to their alcohol intake, and the extent of histological damage assessed. Periportal inflammation was significantly more pronounced in heavy drinkers than in teetotalers. Also important, although expected, is the observation of a greater fibrosis in heavy drinkers.