Tiribelli C

Language: English
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Page: 239
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Liver dysfunction in steady state sickle cell disease, by Taiwo Kotila et al.

Although patients with sickle cell anemia (SCA) may present t liver dysfunction, the extent of involvement of the liver in this condition is unclear. The hepatic complications of SCA disorders can be related to hemolysis and/or to the outcome of massive transfusion regimen such as HBV or HCV infection. The paper by Kotila addresses this topic by analyzing a sufficiently large number of patients with SCA and assessing liver function by the common tests. The conclusion is that liver is minimally involved in the SCA since the was majority of case showed normal ALT/AST values; the alteration in alkaline phosphatase may be due to extra-hepatic involvement.