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ISSN 0210-5187 (Electronic)

2007, Number 3

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Med Cutan Iber Lat Am 2007; 35 (3)

Improvement of simple bullous epidermolysis with tetracycline: an example of single patient (N-of-1) clinical trial in dermatology

García-Doval I, Abalde MT, Olivera R, Feal C, Torre C, Conde-Taboada A, Mayo-Pampín E, González-Sixto B, Flórez A, Rosón E, Cruces MJ

Language: Spanish
References: 13
Page: 159-163
PDF size: 217.54 Kb.


ABSTRACT

We report a case of epidermolysis bullosa simplex, with singular findings such as late appearance (sixth decade), and associated nephrotic syndrome and demyelinating polyneuropathy. A single patient (N-of-1) clinical trial established the usefulness of tetracycline therapy (500 mg/8 h) to diminish the number of new bullae. This report serves as an example of the use of single patient clinical trials in dermatology.


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