2003, Number 4
An Med Asoc Med Hosp ABC 2003; 48 (4)
Martínez IKeren-Happuch, Simón DJ
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ABSTRACTBackground: Cystatin C is a protein derived from all nucleated cells; it is filtered only through glomeruli and metabolized at tubular level, hence is an ideal marker to renal function. Patients and methods: A cross-sectional study was performed during the period from June 1st to August 30th 2003 in the ABC Medical Center in a group of 84 patients that included 27 healthy people, 33 with probable nephropathy and 24 with diagnosed nephropathy by renal biopsy. They were measured creatinine and serum cystatin C and clearance of creatinine in a sample of urine of 24 hours corrected by area of corporal surface. A second group of 419 healthy people was studied to obtain the values of reference of cystatin C. Results: Cystatin C showed bigger correlation when detecting lightly diminished clearance (r = 0.98 p ‹ 0.01) contrary to serum creatinine (r = 0.84 p ‹ 0.01). The second group showed a normal distribution, and the people’s 95% presented levels of cystatin C of 0.53-0.93 mg/L. Conclusion: Serum cystatin C is a more sensitive test to detect renal damage early.