Tiribelli C

Language: English
References: 0
Page: 67
PDF size: 0. Kb.

Text Extraction

The relationship between alteration in cholesterol absorption and biliary excretion, obesity and gallstone formation are clinically known since more than 50 years. More recently the presence of gallstones has been associated with the so called “metabolic syndrome” reiterating the role of obesity in the development of this common disorder. Leptin is a key player in obesity since regulates energy consumption. Leptin acts via the leptin receptor (LEPR), and a reduced interaction and/or a reduced functional expression of LEPR result in hyperleptinemia, which has been associated with obesity. Since leptin regulates the cholesterol biliary excretion, it would be of interests to understand if alterations of LEPR may be associated with a different the risk of cholesterol gallstones.