Tiribelli C, Rigato I

Language: English
References: 2
Page: 201
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The liver accomplishes multiple functions such as the biotransformation of insoluble compounds (drugs, toxins, bilirubin), the metabolism and excretion of lipids (cholesterol in particular) the production of several plasma proteins (good examples are albumin, coagulation factors, transferrin), and the metabolism of amino acids and carbohydrates. The liver also plays a crucial role in the metabolism of different hormones, estrogens and progesterone among the others. This explains why during a chronic liver disease (CLD) severe alteration on the hormonal status occurs. Cirrhosis is often associated with amenorrhea and consequently, women with CLD (cirrhosis obviously included) have difficulty conceiving. If pregnancy occurs, it is associated with an increased risk of complications. Approximately 15 to 20 percent of pregnant women with CLD suffer spontaneous abortion, increased risk for premature childbirth or stillbirth.

REFERENCES

1. Lee WM. Pregnancy in patients with chronic liver disease. Gastroenterol Clin North Am 1992; 21: 889-903.

2. Garcia-Tsao G. Portal hypertension. Curr Opin Gastroenterol 2006; 22: 254-62.