Tiribelli C

Language: English
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Page: 203
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Dipeptidyl Peptidase IV (DDP IV) in NASH Patients

Nonalcoholic steatohepatitis (NASH), a potential cause of end-stage liver disease and hepatocellular carcinoma, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. Although in the last 5 years considerable progress has been made in the understanding of the molecular and cellular mechanisms implicated in the pathogenesis of NASH, the inner events at the basis of the accumulation of triglycerides in the hepatocytes is still not fully clarified. Comprehension of the basic mechanisms of NASH development is critical to design novel diagnostic and therapeutic strategies. Dipeptidyl peptidase IV (DPP IV) is a cell-surface dipeptidase that inactivates peptides by removing proline or alanine from the 2^nd position of the N-terminal. By inactivating incretins DPPIV also improves insulin resistance and β cell function.