Ziad Aboharp Hasan, José Luis Zaragoza, Xicoténcatl Jiménez Villanueva, Francisco García Rodríguez, Martha Lilia Tena Suck, Hugo Roberto Molina Cárdenas

Language: Spanish
References: 8
Page: 303-306
PDF size: 89.95 Kb.

ABSTRACT

Multiple osteochondromatosis is a familiar disorder of autosomal dominant transmission marked by the development of multiple exostosis and often derangement of epiphyseal cartilage. The age of onset is 31 years. Patients with the disorder seem to be at an increased risk for developing secondary chondrosarcoma. We report the case of a 21 year old woman with multiple osteochondromatosis who developed a fatal chondrosarcoma. Radiographically the neoplasm arose from the pelvis completely destroying the pubis. After hemi-pelvectomy the patient underwent postoperative chemotherapy and radiotherapy. On pathologic examination the tumor was diagnosed as a low grade chondrosarcoma. She died of pulmonary metastasis.

REFERENCES

1. Willms R, Harywig CH, Böhm P, Sell S: Malignant transformation of multiple cartilaginous exostosis, a case report. International Ortopedics (SICOT) 1997; 21: 133-6.

2. Kilpatrick SE, Pike EJ, Ward W, Pope TL: Dedifferentiated chondrosarcoma in patients with multiple osteochondromatosis: Report a case and review of the literature. Skeletal Radiol 1997; 26: 370-4.

3. Jaffe HL: Tumors and tumorous conditions of the bones and joints. Philadelphia: Lea & Febiger; 1958.

4. Peterson HA: Multiple hereditary osteochondromata. Clin Orthop 1989; 239: 222-30.

5. Kenan S, Abdelwahab IF, Kleim MJ, Levis MM: Case report 817. Skeletal Radiology 1993; 22: 623-6.

6. Huvos AG: Bone tumors, diagnosis, treatment and prognosis. Philadelphia, London, Toronto: Saunders; 1975.

7. Garrison RC, Unni KK, Mac Leod RA, Pritchard DJ: Condrosarcoma arising in osteochondroma. Cancer 1992; 49: 1890-7.

8. Buckley RH: Immunodeficiency disease. JAMA 1987; 285: 2841.