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Asociación Mexicana de Gastroenterología
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2006, Number 3

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Rev Gastroenterol Mex 2006; 71 (3)

Hereditary nonpolyposis colorectal cancer (Lynch syndrome). Clinical case

Torres-Machorro A, Aragón-Anzures A, Barrera-Pérez M, Chávez-Tapia NC, Valdovinos Ma
Full text How to cite this article

Language: Spanish
References: 11
Page: 312-315
PDF size: 60.32 Kb.


Key words:

Hereditary colorectal, Lynch syndrome.

ABSTRACT

Colorectal cancer is an important neoplasm in general population, about 90% of the cases are sporadical, but near of 5% are due to hereditary non polyposis colorectal cancer. Early detection is imperative due to genetic linkage and association to other neoplasms diagnosed an early age. This case report is about a young man diagnosed with colorectal cancer that presented multiple recurrences and had at least two affected generations. The most important aspects of diagnosis, management and genetic counseling are discussed.


REFERENCES

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  2. Dirección General de Epidemiología. Compendio de Cáncer 2000 Morbilidad/Mortalidad de la SSA. Vol. 2006. Secretaría de Salud, 2001.

  3. Wheeler JM, Bodmer WF, Mortensen NJ. DNA mismatch repair genes and colorectal cancer. Gut 2000; 47: 148-53.

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  5. Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999; 116: 1453-6.

  6. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004; 96: 261-8.

  7. Umar A, Risinger JI, Hawk ET, Barrett JC. Testing guidelines for hereditary non-polyposis colorectal cancer. Nat Rev Cancer 2004; 4: 153-8.

  8. de Vos tot Nederveen Cappel WH, Buskens E, van Duijvendijk P y cols. Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. Gut 2003; 52: 1752-5.

  9. Jarvinen HJ. Genetic testing for polyposis: practical and ethical aspects. Gut 2003; 52(Suppl. 2): 19-22.

  10. Bradshaw N, Holloway S, Penman I, et al. Colonoscopy surveillance of individuals at risk of familial colorectal cancer. Gut 2003; 52: 1748-51.

  11. Kievit W, de Bruin JH, Adang EM, et al. Cost effectiveness of a new strategy to identify HNPCC patients. Gut 2005; 54: 97-102.




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Rev Gastroenterol Mex. 2006;71